Category: 149809-43-8

149809-43-8, Name is ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate, belongs to tetrahydrofurans compound, is a common compound. Related Products of 149809-43-8In an article, once mentioned the new application about 149809-43-8.

A series of azolylmethyloxolane derivatives with modified sterol side-chain structures, designed as potential dual functional inhibitors of cytochrome P450 14alpha-demethylase (14DM) and Delta24-sterol methyltransferase (24-SMT) based on the common characteristic features of 24-aminosterols and azole antifungal agents, were synthesized and evaluated for their antifungal activities and inhibitory activities of 14DM and 24-SMT. Among these compounds, imidazolylmethyloxolane derivatives 28a and 28b showed potent in vitro antifungal activities comparable to those of itraconazole. However, the in vitro bioactivities have not been linearly translated into in vivo protection data for some unknown reasons. Copyright (C) 2000 Elsevier Science Ltd.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chemistry involves the study of all things chemical – chemical processes, chemical compositions and chemical manipulation – in order to better understand the way in which materials are structured, how they change and how they react in certain situations. COA of Formula: C21H21F2N3O4S

The invention discloses a method for preparation of posaconazole, first of all, BP004b04 with oxalic acid to form the salt, to obtain the POE; secondly, POE with di-tert-butyl b carbon ester in the presence of an alkali reaction to obtain POP, POP recrystallization; once again, with the POK POP in the presence of an alkali reaction to obtain the POR, POR removes uncle butyl carbonate protecting group, to obtain POS; finally POS POB ring obtained, with the POB POA reaction posaconazole. The method of the invention, obtained in the posaconazole, the diastereoisomeric isomer content ? 0.01%, and the whole route total yield is high. (by machine translation)

A catalyst does not appear in the overall stoichiometry of the reaction it catalyzes. In my other articles, you can also check out more blogs about 149809-43-8. COA of Formula: C21H21F2N3O4S

Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chemistry involves the study of all things chemical – chemical processes, chemical compositions and chemical manipulation – in order to better understand the way in which materials are structured, how they change and how they react in certain situations. Electric Literature of 149809-43-8

This invention discloses a process for preparing the formula 1 shown in the process for the preparation of posaconazole intermediate compound 1 method. Preparation method of the invention is compound have been reported in the literature for 2 as raw material, first of all three alkyl silicon-based protection of hydroxy to obtain compound 3, then with the triazole sodium salt of 4 reaction, to obtain compound 5, then in toluene sulfonyl chloride and alkali escapes the silicon ether and perform under the action of toluene sulfonyl protection to obtain compound 1. The invention can overcome the disadvantages of the prior art, and does not pass the splitting step, reduced side reaction occurs and impurity appear, improves the reaction selectivity and yield. (by machine translation)

Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about 149809-43-8. Electric Literature of 149809-43-8

Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Application of 149809-43-8, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 149809-43-8, Name is ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate,introducing its new discovery.

This invention relates to a compound, as defined in the specification, useful in the treatment of mycoses, compositions containing it and its use in therapy.

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Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Application In Synthesis of ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 149809-43-8, name is ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate. In an article，Which mentioned a new discovery about 149809-43-8

Porcine pancreatic lipase (PPL) catalysis has been used to establish both stereocenters of the cis-(tetrahydrofuranylmethyl) tosylate 4. In addition to the enzymatic differentiation of the hydroxyl groups of the pro-chiral 1,3-diol segment of 2, successful enzymatic resolution of the racemic diol 10 provided an alternate route to the important precursor 1.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 149809-43-8, help many people in the next few years.Application In Synthesis of ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate

Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Application of 149809-43-8, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 149809-43-8, ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate, introducing its new discovery.

The present invention provides an industrial method production of amorphous posaconazole. The present invention also relates to a method for production of the posaconazole via and novel crystalline forms of posaconazole intermediate. More particularly the present invention relates to novel crystalline forms of posaconazole intermediate and methods for production of novel crystalline forms of posaconazole intermediate represented by the following structural formula III Which is key intermediate in the production of posaconazole. The present invention also provides for the one pot process for the preparation of amorphous posaconazole using novel crystalline forms of benzyl posaconazole.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 149809-43-8. In my other articles, you can also check out more blogs about 149809-43-8

Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 149809-43-8, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 149809-43-8, Name is ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate, molecular formula is C21H21F2N3O4S

The new heterocycle compound ((3S,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate (1), designed using ((3R,5S)-5-(2,4-difluorophenyl)-5-iodotetrahydrofuran-3-yl)methyl isobutyrate (2) as the start material, was successfully obtained via multiple synthesis route and finally characterized by IR, 1H NMR, and single-crystal X-ray crystallography. In addition, the in vitro anticancer activities of the newly synthesized complex 1 have been emulated against three human breast cancer cell lines BT474, MCF7 and MB.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: 149809-43-8, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 149809-43-8, in my other articles.

Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Synthetic Route of 149809-43-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.149809-43-8, Name is ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate, molecular formula is C21H21F2N3O4S. In a Patent，once mentioned of 149809-43-8

This invention relates to compounds, as defined in the specification, useful in the treatment of mycoses, to compositions containing them and to their use in therapy.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 149809-43-8, and how the biochemistry of the body works.Synthetic Route of 149809-43-8

Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Related Products of 149809-43-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.149809-43-8, Name is ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate, molecular formula is C21H21F2N3O4S. In a Patent£¬once mentioned of 149809-43-8

The invention belongs to the field of medical technology, relates to a method of preparing intermediates of posaconazole, and the intermediate for the preparation of a new method of posaconazole. The method comprises the following steps: a) of formula III compound of the formula IV compound under alkaline condition, for […] etherification reaction in a solvent to obtain the compound of formula V; b) type V compounds of palladium and formic acid under the conditions of the reaction intermediate type II compounds posaconazole; c) of formula II compound alkali hydrolysis reaction to obtain the posaconazole. The method of the invention compared with the known method of the invention, the invention is a process for preparing posaconazole intermediate II of the new method, and the intermediate II alkali hydrolysis to obtain the final product posaconazole I; compared with the prior process, the new process of the present invention purified difficulty is greatly reduced, greatly reduces the impurity of the product, significantly improving the purity, reduces the amount of heavy crystallization times, improves the yield, and reduces the production cost, the operation is simple, safe and reliable, is extremely suitable for industrial production. (by machine translation)

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 149809-43-8

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Formula: C21H21F2N3O4S, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 149809-43-8, Name is ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate, molecular formula is C21H21F2N3O4S

PROCESS FOR THE PREPARATION OF A CHIRAL COMPOUND

The present invention relates to a process for the preparation of a compound of formula (V), in particular posaconazole, wherein said process comprises the steps of (1) providing a mixture comprising a compound of formula (IV), a protic solvent system, and a suitable base; and (2) heating the mixture of (1) to obtain a mixture comprising the compound of formula (V).

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Formula: C21H21F2N3O4S, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 149809-43-8, in my other articles.

Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem