Category: 144870-96-2

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.144870-96-2,4-Aminotetrahydrofuran-3-ol,as a common compound, the synthetic route is as follows.

A solution of compound 2 (360 g, 3.5 mmol) in THF (10 mL) was added (Boc)20 (1.14 g,5.25 mmol) and NaOH (2N, 2 mL), then stirred at RT for 1 h. Quenched with water and extractedwith EtOAc, dried and evaporated, purified by combiflash (methanol:DCM = 1:20) to give compound 3 (0.2 g, 28%). LC-MS: m/z = 104.0 [M+H-Boc]

144870-96-2, The synthetic route of 144870-96-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ABBVIE INC.; MICHAELIDES, Michael; HANSEN, Todd; DAI, Yujia; ZHU, Guidong; FREY, Robin; GONG, Jane; PENNING, Thomas; CURTIN, Michael; MCCLELLAN, William; CLARK, Richard; TORRENT, Maricel; MASTRACCHIO, Anthony; KESICKI, Edward A.; KLUGE, Arthur F.; PATANE, Michael A.; VAN DRIE, John H. Jr.; JI, Zhiqin; LAI, Chunqiu C.; WANG, Ce; (1190 pag.)WO2016/44770; (2016); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

144870-96-2, 4-Aminotetrahydrofuran-3-ol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 4-aminotetrahydrofuran-3-ol (74.5 mg, 0.722 mmol) and ethyl 4-(chlorosulfonyl)-3-fluoro-l-methyl-lH-pyrrole-2-carboxylate (150 mg, 0.556 mmol) in dry acetonitrile (4 mL), dry DIPEA (0.3 mL, 1.7223 mmol) was added at rt. After lh mixture was evaporated under reduced pressure to afford a yellow solid (325 mg). Crude was purified by flash chromatography (Petroleum ether/ AcOEt) to afford D44 as a light yellow solid (178 mg, y= 95%). Method 1 : Rt=l.28 min, m/z=337 (M+H)+. The compound is the trans racemic mixture at the tetrahydrofuranyl ring., 144870-96-2

144870-96-2 4-Aminotetrahydrofuran-3-ol 10486809, aTetrahydrofurans compound, is more and more widely used in various.

Reference£º
Patent; OSPEDALE SAN RAFFAELE S.R.L.; IRBM S.P.A.; PROMIDIS S.R.L.; ISTITUTO NAZIONALE DI GENETICA MOLECOLARE – INGM; DE FRANCESCO, Raffaele; DONNICI, Lorena; GUIDOTTI, Luca; IANNACONE, Matteo; DI FABIO, Romano; SUMMA, Vincenzo; PRANDI, Adolfo; RANDAZZO, Pietro; GORNATI, Davide; GRILLO, Alessandro; FERRANTE, Luca; BENCHEVA, Leda Ivanova; DE MATTEO, Marilenia; FERRARA, Marco; (238 pag.)WO2020/30781; (2020); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem