Category: 14166-28-0

Polonski, Tadeusz;Milewska, Maria J.;Gdaniec, Maria;Gilski, Miroslaw published 《Molecular geometry and circular dichroism spectra of bicyclo[2.2.1]heptane-2,3-dicarboxylic anhydrides and imides》 in 1993. The article was appeared in 《Journal of Organic Chemistry》. They have made some progress in their research.Category: tetrahydrofurans The article mentions the following:

Several tricyclic anhydrides and imides derived from optically active bicyclo[2.2.1]heptane-2,3-dicarboxylic acids were synthesized, and their CD spectra are reported. On the basis of MNDO calculations it was estimated that despite rigidity of the norbornane system, the five-membered rings of succinic anhydride and imide moieties are slightly twisted. The chromophores are flexible and can be more or less skewed depending on solvent polarity. The chromophore nonplanarity significantly influences magnitude and sign of the first Cotton effect associated with the lowest energy n-π^* electronic transition. The sign of the second n-π^* Cotton effect is governed by vicinal effect of substituents. The crystal structures of three N-(S)-1-phenylethylimides were solved to estimate the configuration of C-2 of the imide moieties.(3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methanoisobenzofuran-1,3-dione (cas: 14166-28-0) were involved in the experimental procedure.

In the laboratory, (3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methanoisobenzofuran-1,3-dione(14166-28-0) is a popular solvent when its water miscibility is not an issue. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes.Category: tetrahydrofurans It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Recommanded Product: (3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methanoisobenzofuran-1,3-dione《Study of Chemical Shift Variations in Tricyclic Urazoles with a Norbornane Skeleton》 was published in 2006. The authors were Bentz, Timothy;Ryzhkov, Lev, and the article was included in《Spectroscopy Letters》. The author mentioned the following in the article:

Mols. related to norbornane commonly serve as useful models for stereochem. and conformational anal., as well as for elucidation of steric and electronic substituent effects. Chem. shifts of their bridge protons are well tabulated and follow clear, easily predictable patterns. For example, the exo protons on a two-carbon bridge of these mols. are typically deshielded relative to the endo protons. Previously, some exceptions to this rule were noted and satisfactorily explained. In tricyclic urazoles, common precursors to cyclic diazenes, the order of chem. shifts of exo and endo bridge protons is reversed. The authors use aromatic solvent induced shifts (ASIS) and homodecoupling experiments to assign ¹H-NMR signals in these urazoles and bridge proton signals in model mols., and the authors discuss anal. of factors that influence chem. shifts in this polycyclic system. The experimental procedure involved many compounds, such as (3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methanoisobenzofuran-1,3-dione (cas: 14166-28-0) .

In the laboratory, (3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methanoisobenzofuran-1,3-dione(14166-28-0) is a popular solvent when its water miscibility is not an issue. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes.Recommanded Product: (3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methanoisobenzofuran-1,3-dione It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ishizumi, Kikuo;Kojima, Atsuyuki;Antoku, Fujio published 《Synthesis and anxiolytic activity of N-substituted cyclic imides (1R*,2S*,3R*,4S*)-N-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,3-bicyclo[2.2.1]heptanedicarboximide (tandospirone) and related compounds》 in 1991. The article was appeared in 《Chemical & Pharmaceutical Bulletin》. They have made some progress in their research.Application of 14166-28-0 The article mentions the following:

A series of cyclic imides bearing ω-(4-aryl and 4-heteroaryl-1-piperazinyl)alkyl moieties, e.g., I, was synthesized and tested in vivo for anxiolytic activity. The in vitro binding affinities of these compounds were also examined for 5-HT_1A receptor sites. Structure-activity relationships within the series are discussed. Tandospirone (I) was equipotent with buspirone in its anxiolytic activity and more anxio-selective than buspirone and diazepam. I is currently undergoing clin. evaluation as a selective anxiolytic agent.(3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methanoisobenzofuran-1,3-dione (cas: 14166-28-0) were involved in the experimental procedure.

In the laboratory, (3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methanoisobenzofuran-1,3-dione(14166-28-0) is a popular solvent when its water miscibility is not an issue. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes.Application of 14166-28-0 It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Zhou, Zheng Hong;Chen, Ru Yu published 《Synthesis of 1,2-cyclic monoacyl-rac-glycerothiophosphates of cantharidin analogues》 in 2000. The article was appeared in 《Phosphorus, Sulfur and Silicon and the Related Elements》. They have made some progress in their research.HPLC of Formula: 14166-28-0 The article mentions the following:

1,2-Cyclic monoacyl-rac-glycerothiophosphates of cantharidin and its analogs, e.g., I (R = H, X = O, CH₂) were synthesized in a 1-pot procedure in overall yields of 44-55.5% by P(NEt₂)₃, activated by a catalytic amount of iodine, as phosphorylating reagent, acting on N-hydroxyethyl exo-(7-oxa)bicyclo[2.2.1]heptene-2,3-dicarboximide followed by a cyclocondensation with monostearin. Their structures were confirmed by ¹H NMR, ³¹P NMR, IR and elemental anal. The experimental procedure involved many compounds, such as (3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methanoisobenzofuran-1,3-dione (cas: 14166-28-0) .

In the laboratory, (3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methanoisobenzofuran-1,3-dione(14166-28-0) is a popular solvent when its water miscibility is not an issue. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes.HPLC of Formula: 14166-28-0 It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

To, Kenneth K. W.;Wang, Xinning;Yu, Chun Wing;Ho, Yee-Ping;Au-Yeung, Steve C. F. published 《Protein phosphatase 2A inhibition and circumvention of cisplatin cross-resistance by novel TCM-platinum anticancer agents containing demethylcantharidin》. The research results were published in《Bioorganic & Medicinal Chemistry》 in 2004.COA of Formula: C9H10O3 The article conveys some information:

Novel TCM-platinum compounds [Pt(C₈H₈O₅)(NH₂R)₂], derived from integrating demethylcantharidin, a modified component from a traditional Chinese medicine (TCM) with a platinum moiety, possess anticancer and protein phosphatase 2A (PP2A) inhibition properties. The compounds are able to circumvent cisplatin resistance by apparently targeting the DNA repair mechanism. Novel isosteric analogs [Pt(C₉H₁₀O₄)(NH₂R)₂], devoid of PP2A-inhibitory activity, were found to suffer from an enhanced DNA repair and were cross-resistant to cisplatin. The results advocate a well-defined structure-activity requirement associating the PP2A-inhibiting demethylcantharidin with the circumvention of cisplatin cross-resistance demonstrated by TCM-Pt compounds(3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methanoisobenzofuran-1,3-dione (cas: 14166-28-0) were involved in the experimental procedure.

In the laboratory, (3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methanoisobenzofuran-1,3-dione(14166-28-0) is a popular solvent when its water miscibility is not an issue. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes.COA of Formula: C9H10O3 It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem