Category: 13146-72-0

Hypotensive compounds isolated from the dried body of Naja naja Kaouthia Lesson. I. Isolation of inosine as a hypotensive principle and structure-activity study of related compounds was written by Tsujibo, Hiroshi; Taniguchi, Toru; Koyama, Isao; Kubo, Mayuri; Inamori, Yoshihiko. And the article was included in Chemical & Pharmaceutical Bulletin on April 25,1986.Computed Properties of C10H12N4O4  The following contents are mentioned in the article:

From the dried body of N. naja, inosine (I) [58-63-9] was isolated as 1 of the 3 hypotensive compounds after Sephadex G-25 chromatog. and purification by preparative HPLC. Hypotensive activity was observed at dose levels higher than 0.5 mg/kg, the activity strongly increasing with increasing I dose. However, at 0.1 and 0.25 mg/kg, I showed only a transient effect and the blood pressure recovered to the original level within one min. 2′-Deoxyinosine  [890-38-0] and 3′-deoxyinosine  [13146-72-0] completely lacked hypotensive activity. Phosphorylation at the 3′- or 5′-position of the ribose moiety slightly decreased the hypotensive activity. However, inosine 5′-diphosphoribose  [86-04-4] showed the most potent hypotensive activity among compounds tested. Hydroxyl groups at C-2′ and C-3′ are necessary for I to show the activity. The importance of the ribose configuration of the sugar moiety of I for the hypotensive activity was demonstrated. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Computed Properties of C10H12N4O4 ).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF) is a Lewis base that bonds to a variety of Lewis acids such as I2, phenols, triethylaluminum and bis(hexafluoroacetylacetonato)copper(II). Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Computed Properties of C10H12N4O4 

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

The action of adenosine deaminase (E.C. 3.5.4.4.) on adenosine and deoxyadenosine acetates: the crucial role of the 5′-hydroxy group for the enzyme activity was written by Ciuffreda, Pierangela; Casati, Silvana; Santaniello, Enzo. And the article was included in Tetrahedron on May 12,2000.Formula: C10H12N4O4  The following contents are mentioned in the article:

From adenosine, 2′-deoxyadenosine, and 3′-deoxyadenosine all the acetates were prepared by lipase-catalyzed reactions. Only the acetates with free 5′-hydroxy group were deaminated by adenosine deaminase (ADA), confirming the crucial role of 5′-OH for the enzyme activity. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Formula: C10H12N4O4 ).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. Tetrahydrofurans and furans are important oxygen-containing heterocycles that often exhibit interesting properties for biological applications or applications in the cosmetic industry. Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.Formula: C10H12N4O4 

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Gene therapy of cancer: activation of nucleoside prodrugs with E. coli purine nucleoside phosphorylase was written by Secrist, John A. III; Parker, William B.; Allan, Paula W.; Bennett, L. Lee Jr.; Waud, William R.; Truss, Jackie W.; Fowler, Anita T.; Montgomery, John A.; Ealick, Steven E.; Wells, Alan H.; Gillespie, G. Yancey; Gadi, V. K.; Sorscher, Eric J.. And the article was included in Nucleosides & Nucleotides on May 31,1999.Application In Synthesis of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol The following contents are mentioned in the article:

During the last few years, many gene therapy strategies have been developed for various disease targets. The development of anticancer gene therapy strategies to selectively generate cytotoxic nucleoside or nucleotide analogs is an attractive goal. One such approach involves the delivery of herpes simplex virus thymidine kinase followed by the acyclic nucleoside analog ganciclovir. We have developed another gene therapy methodol. for the treatment of cancer that has several significant attributes. Specifically, our approach involves the delivery of E. coli purine nucleoside phosphorylase, followed by treatment with a relatively non-toxic nucleoside prodrug that is cleaved by the enzyme to a toxic compound This presentation describes the concept, details our search for suitable prodrugs, and summarizes the current biol. data. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Application In Synthesis of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.Application In Synthesis of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Sequencing-by-ligation using oligonucleotide probes with 3′-thio-deoxyinosine was written by Pu, Dan; Chen, Jing; Bai, Yunfei; Tu, Jing; Xie, Hongmei; Wang, Wenjie; Xiao, Pengfeng; Lu, Zuhong. And the article was included in Journal of Biomedical Nanotechnology on May 31,2014.Product Details of 13146-72-0 The following contents are mentioned in the article:

We have developed a novel sequencing-by-ligation (SBL) system employing oligonucleotide probes containing 3′-thio-deoxyinosine on a microarray. The oligonucleotide probes were synthesized from 3′-S-(2-cyanoethyl-N,N-diisopropylphosphorothioamidite)-5′-O-(4,4′ dimet-hoxytrityl) deoxyinosine. The resultant probes could be cleaved chem. by aqueous silver ions under mild conditions, generating a 5′-terminal phosphate group in a degradation oligodeoxynucleotide fragment. This 5′-terminal phiosphate was used directly for detecting the corresponding bases in subsequent sequencing cycles. The queried bases in the template were identified with eight cycles of ligation and cleavage. The read length of our method could reach up to 40 bp with high accuracy. As this SBL method uses com. available enzymes and standard microarrays, it will be amenable to automation and adaptation by the research community. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Product Details of 13146-72-0).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. Tetrahydrofuran can also be produced, or synthesised, via catalytic hydrogenation of furan. This process involves converting certain sugars into THF by digesting to furfural. An alternative to this method is the catalytic hydrogenation of furan with a nickel catalyst.Product Details of 13146-72-0

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Differential nucleoside recognition during Bacillus cereus 569 (ATCC 10876) spore germination was written by Abel-Santos, Ernesto; Dodatko, Tetyana. And the article was included in New Journal of Chemistry on May 31,2007.Formula: C10H12N4O4  The following contents are mentioned in the article:

The authors have tested a series of inosine analogs for their effect on germinating B. cereus 569 spores. The results showed that although inosine (hypoxanthine nucleoside) causes spore germination by itself, the kinetic pathway exhibited complex and strongly cooperative character. Contrary to inosine’s germinating effect, the purine pathway degradation products xanthine, xanthosine, uric acid, hypoxanthine, ribose, or ribose plus hypoxanthine failed to activate spore germination. Furthermore, even small modifications of inosine’s nucleobase or sugar moieties have deleterious effects on germination efficiency. In contrast to previous work with the B. cereus 3711 strain, incubation of B. cereus 569 spores with adenosine (6-aminopurine riboside) did not trigger germination, but prevented inosine-mediated germination. The inhibitory effect was lost if adenosine was substituted with adenine alone, or ribose plus adenine. Although adenosine is able to block inosine-mediated germination, it acts as a co-germinant in the presence of alanine. Nucleosides that have substitutions in the purine base are not able to trigger germination by themselves, but can act as co-germinants in the presence of sub-germinant concentrations of alanine. In contrast, modifications of the sugar moiety precluded germination activity under all conditions tested. The data suggests that only inosine can activate germination by itself. However, when alanine is present as a co-germinant, different germination receptors are activated that recognize a larger subset of nucleoside structures. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Formula: C10H12N4O4 ).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.Formula: C10H12N4O4 

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Adenosine receptor activation in human fibroblasts: nucleoside agonists and antagonists was written by Bruns, Robert F.. And the article was included in Canadian Journal of Physiology and Pharmacology on June 30,1980.HPLC of Formula: 13146-72-0 The following contents are mentioned in the article:

Adenosine [58-61-7] (ED50 15 μM) causes a 50-fold increase in intracellular cyclic AMP in the VA13 human fibroblast line. A total of 128 nucleosides was tested as agonists and antagonists. Eight classes of compounds were found: full agonists (14 compounds), weak agonists (20), high-efficacy partial agonists (16), low-efficacy partial agonists (7), competitive inhibitors (11), noncompetitive inhibitors (3), partial agonist – noncompetitive inhibitors (3), and inactive compounds (54). The noncompetitive inhibitors antagonized the responses to adenosine, isoproterenol, and prostaglandin E1 and thus may have been adenylate cyclase inhibitors. The most potent noncompetitive inhibitor, 2′,5′-dideoxyadenosine [6698-26-6] was a partial inhibitor, reducing the response to isoproterenol by only 77% even at very high concentrations The most potent agonists, partial agonists, and pure antagonists had apparent affinities of about 5 μM. Although all positions were important for affinity at the adenosine receptor, only the 3′- and 5′-positions and to a much lesser extent the 6- and 8-positions had an effect on efficacy. The receptor tolerated bulky groups at the 6-position of adenosine, had an Et-sized pocket near the 5′-position, and had little bulk tolerance towards modifications at other positions. Among the full agonists, only one 5′-derivative and one 2-position derivative had higher apparent affinity than adenosine. Studies with conformationally restricted agonists and antagonists showed that adenosine must be in the anti conformation in order to bind to the receptor. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0HPLC of Formula: 13146-72-0).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. Tetrahydrofurans and furans are important oxygen-containing heterocycles that often exhibit interesting properties for biological applications or applications in the cosmetic industry. Tetrahydrofuran (THF) is primarily used as a precursor to polymers including for surface coating, adhesives, and printing inks.HPLC of Formula: 13146-72-0

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Toxicity and metabolism of 3′-deoxyadenosine N1-oxide in mice and Ehrlich ascites tumor cells was written by Svendsen, Karsten Ramlov; Overgaard-Hansen, Kay; Frederiksen, Sune; Engelholm, Svend Aage; Pedersen, Niels Tinggaard; Vindelov, Lars Lindhardt. And the article was included in Cancer Chemotherapy and Pharmacology on June 30,1992.Name: 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol The following contents are mentioned in the article:

The toxic effect of 3′-deoxyadenosine N1-oxide (DANO) on mice, on their organs, and on Ehrlich ascites tumor cells was studied. In both healthy and tumor-bearing animals, the i.p. LD10 of DANO was about 300 mg/kg for 4 days in the Theiller mouse strain. In the NMRI strain, a markedly higher LD10 value (675 mg/kg for 5 days) was found. At nonlethal doses (250 mg/kg for 4 days), reversible neurol. symptoms were observed on days 4-12 after treatment, but no macroscopical or microscopical changes were detected in the brain, heart, thymus, lung, lymph nodes, spleen, liver, kidney, bone marrow, or gastrointestinal tract. At doses of 450 mg/kg for 4 days, severe neurol. symptoms, atony of the gastrointestinal canal, and damage to the kidney and liver were found. Even at doses that were lethal to mice, no histopathol. changes were observed in the bone marrow or in the gastrointestinal tract. After i.p. injection of DANO, the maximal blood plasma concentration was reached after 10 min, after which it declined showing a half-life of about 40 min. A transient accumulation of 3′-deoxyadenosine triphosphate (3′-dATP) was observed within 24 h in the liver and kidney, with the maximal concentration being reached after about 2-3 h. DANO was excreted partly as the unchanged substance and partly as 3′-deoxyinosine metabolite within 24 h. Flow-cytometric DNA anal. of Ehrlich tumor cells treated in vitro or in vivo with DANO revealed no therapy-induced perturbations of the cell cycle, which indicates that the cells were killed randomly during all phases of the cycle. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Name: 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. Tetrahydrofurans and furans are important oxygen-containing heterocycles that often exhibit interesting properties for biological applications or applications in the cosmetic industry. Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.Name: 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Leishmania donovani: pilot study for evaluation of therapeutic effects of inosine analogs against amastigotes in vitro and in vivo was written by Morishige, Kazuhisa; Aji, Toshiki; Ishii, Akira; Yasuda, Tatsuji; Wataya, Yusuke. And the article was included in Experimental Parasitology on June 30,1995.COA of Formula: C10H12N4O4  The following contents are mentioned in the article:

The inhibition by carbocyclic inosine (C-Ino), 3′-deoxyinosine (3′-dI), and 3′-deoxy-3′-fluoroinosine (3′-FI) of Leishmania donovani amastigotes was examined J774.1 cells (a mouse macrophage line) were cultured in GIT medium with lipopolysaccharide and hemin and infected with the parasite. C-Ino (3 μM) completely inhibited and 3′-dI (30 μM) reduced to 40% the infection rate on Day 6 after infection. The standard pentostam (30 μM) resulted in a 38% infection rate. The therapeutic efficacies of nonentrapped free and liposome-entrapped inosine analogs were tested in mice infected with L. donovani. The mice were injected i.v. five times on alternate days, beginning 2 days after infection. Treatment with the nonentrapped free inosine analog of C-Ino (100 mg/kg), 3′-dI (100 mg/kg), or 3′-FI (50 mg/kg) resulted in an LDU (Leishmania donovan units) that were 94, 68, or 73% lower, resp., than the control values. Treatment with the corresponding entrapped inosine analog (10 mg/kg) caused decreases of 90, 69, or 68% LDU, resp. The entrapped inosine analogs were inhibitory at doses one-fifth to one-tenth of the nonentrapped free inosine analogs. C-Ino had the strongest inhibitory effect among the three analogs tested in vitro and in vivo. Liposome-entrapped C-Ino had no severe side effects, although spleen weight increased. The agent may be useful as an antileishmanial drug. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0COA of Formula: C10H12N4O4 ).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. Tetrahydrofuran can also be produced, or synthesised, via catalytic hydrogenation of furan. This process involves converting certain sugars into THF by digesting to furfural. An alternative to this method is the catalytic hydrogenation of furan with a nickel catalyst.COA of Formula: C10H12N4O4 

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Antiprotozoal activity of 3′-deoxyinosine. Inverse correlation to cleavage of the glycosidic bond was written by Moorman, Allan R.; LaFon, Stephen W.; Nelson, Donald J.; Carter, Heidi H.. And the article was included in Biochemical Pharmacology on July 5,1991.Electric Literature of C10H12N4O4  The following contents are mentioned in the article:

Two nucleosides related to the known antiprotozoal agent, allopurinol β-D-riboside) (I) were prepared and evaluated against Leishmania donovani, Trypanosoma cruzi, and T. gambiense. 3′-Deoxyinosine (II) exhibited potent antiprotozoal activity against the three protozoal pathogens with minimal toxicity for host cells. It was especially effective against the Columbia strain of T. cruzi reported to be resistant to I. The antiprotozoal activity of II appeared to be inversely related to the rate of cleavage of the glycosidic bond, as shown by metabolic profiles of II in the various pathogenic hemoflagellates and host cells. Combining the key structural elements of I and II led to the synthesis of 3′-deoxyallopurinol β-D-riboside (III) which was inactive as an antiprotozoal agent. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Electric Literature of C10H12N4O4 ).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. Tetrahydrofuran (THF) is primarily used as a precursor to polymers including for surface coating, adhesives, and printing inks.Electric Literature of C10H12N4O4 

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Nucleoside transporters in Leishmania major: diversity in adenosine transporter expression or function in different strains was written by Baer, Hans P.; Serignese, Vincent; Ogbunude, Patrick O. J.; Dzimiri, Maud. And the article was included in American Journal of Tropical Medicine and Hygiene on July 31,1992.Application In Synthesis of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol The following contents are mentioned in the article:

Cytotoxic nucleoside derivatives may become useful in the treatment of parasitic infections. The effect of a number of nucleosides (100 μM) on the cellular transport of [3H]adenosine and [3H]inosine (each at 1 μM) in promastigotes from 4 L. major strains was investigated. When [3H]inosine was used as permeant, all strains exhibited essentially the same inhibition profile, with unlabeled inosine, guanosine, formycin B, and 3′-deoxyinosine being strongly inhibitory, and adenosine-related compounds such as 2′-deoxyadenosine and tubercidin being inactive. However, when [3H]adenosine was used as permeant, considerable differences in the inhibition profiles were noted among strains. Thus, both inosine transporter-selective nucleosides such as inosine and guanosine and adenosine transporter-selective nucleosides such as 2′-deoxyadenosine and tubercidin showed variable activity as inhibitors of 3H-adenosine transport in different strains. Apparently, an adenosine transporter was variably expressed in different strains, and inhibition profiles for adenosine transport indicated cellular entry via both the inosine and adenosine transporters. The existence of different types of adenosine transporters as an alternative explanation could not be ruled out. The apparent uniform expression of an inosine transporter among different species and strains of Leishmania suggests that inosine derivatives may be useful as anti-leishmanial drugs. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Application In Synthesis of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. Tetrahydrofuran can also be produced, or synthesised, via catalytic hydrogenation of furan. This process involves converting certain sugars into THF by digesting to furfural. An alternative to this method is the catalytic hydrogenation of furan with a nickel catalyst.Application In Synthesis of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0