Category: 13146-72-0

Utilization of 6-methylamino-9-(3′-deoxy-β-D-ribofuranosyl) purine by KB cells was written by Shigeura, Harold T.; Sampson, Susan D.. And the article was included in Biochimica et Biophysica Acta, Nucleic Acids and Protein Synthesis in 1967.HPLC of Formula: 13146-72-0 The following contents are mentioned in the article:

The metabolism of 6-methylamino-9-(3′-deoxy-β-D-ribofuranosyl) purine by KB cells was investigated. The nucleoside was not directly cleaved to the methylated base but instead was slowly demethylated to 3′-deoxyadenosine which metabolized further via 2 sep. pathways: (1) it was converted to 3′-deoxyadenosine 5′-triphosphate and incorporated into RNA, and (2) alternatively, it was catabolized to 3′-deoxyinosine and to hypoxanthine. 16 references. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0HPLC of Formula: 13146-72-0).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.HPLC of Formula: 13146-72-0

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Preparation of halonucleosides was written by Haga, Kazuko; Yoshikawa, Masaharu; Kato, Tetsuya. And the article was included in Bulletin of the Chemical Society of Japan in 1970.Synthetic Route of C10H12N4O4  The following contents are mentioned in the article:

5′-Chloro- (I), 5′-bromo- (II), and 5′-deoxy-5′-iodo-2′,3′-O-isopropylideneinosine (III) are prepared by the treatment of 2′,3′-O-isopropylideneinosine, in (EtO)3PO containing Ph3P, with CCl4, Br, BrCN, and iodine. Similarly, 5′-O-acetylinosine gives 9-(3-chloro-3-deoxy-β-D-xylofuranosyl)-hypoxanthine (IV). I, II, and III are not obtained when the (EtO)3PO is replaced by DMF. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Synthetic Route of C10H12N4O4 ).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. THF can also be synthesized by catalytic hydrogenation of furan. This allows certain sugars to be converted to THF via acid-catalyzed digestion to furfural and decarbonylation to furan, although this method is not widely practiced. THF is thus derivable from renewable resources.Synthetic Route of C10H12N4O4 

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

A Toxoplasma gondii Oxopurine Transporter Binds Nucleobases and Nucleosides Using Different Binding Modes was written by Campagnaro, Gustavo D.; Elati, Hamza A. A.; Balaska, Sofia; Martin Abril, Maria Esther; Natto, Manal J.; Hulpia, Fabian; Lee, Kelly; Sheiner, Lilach; Van Calenbergh, Serge; de Koning, Harry P.. And the article was included in International Journal of Molecular Sciences in 2022.Quality Control of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol The following contents are mentioned in the article:

Toxoplasma gondii is unable to synthesize purines de novo, instead salvages them from its environment, inside the host cell, for which they need high affinity carriers. Here, we report the expression of a T. gondii Equilibrative Nucleoside Transporter, Tg244440, in a Trypanosoma brucei strain from which nucleobase transporters have been deleted. Tg244440 transported hypoxanthine and guanine with similar affinity (Km ∼1 μM), while inosine and guanosine displayed Ki values of 4.05 and 3.30 μM, resp. Low affinity was observed for adenosine, adenine, and pyrimidines, classifying Tg244440 as a high affinity oxopurine transporter. Purine analogs were used to probe the substrate-transporter binding interactions, culminating in quant. models showing different binding modes for oxopurine bases, oxopurine nucleosides, and adenosine. Hypoxanthine and guanine interacted through protonated N1 and N9, and through unprotonated N3 and N7 of the purine ring, whereas inosine and guanosine mostly employed the ribose hydroxy groups for binding, in addition to N1H of the nucleobase. Conversely, the ribose moiety of adenosine barely made any contribution to binding. Tg244440 is the first gene identified to encode a high affinity oxopurine transporter in T. gondii and, to the best of our knowledge, the first purine transporter to employ different binding modes for nucleosides and nucleobases. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Quality Control of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. THF can also be synthesized by catalytic hydrogenation of furan. This allows certain sugars to be converted to THF via acid-catalyzed digestion to furfural and decarbonylation to furan, although this method is not widely practiced. THF is thus derivable from renewable resources.Quality Control of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotidyl transferase-positive (TdT+) leukemic cells was written by Kodama, E. N.; McCaffrey, R. P.; Yusa, K.; Mitsuya, H.. And the article was included in Biochemical Pharmacology in 1999.Related Products of 13146-72-0 The following contents are mentioned in the article:

The nucleoside analog cordycepin (3′-deoxyadenosine, 3′-dA) is substantially more cytotoxic to terminal deoxynucleotidyl transferase pos. (TdT+) leukemic cells than to TdT- leukemic cells in vitro in the presence of an adenosine deaminase inhibitor, deoxycoformycin (dCF), and has been considered as a therapeutic agent for TdT+ leukemia. The intracellular metabolism of 3′-dA was examined with HPLC, and the mechanism of its anti-TdT+ leukemic activity was analyzed. In the presence of dCF (2.5 μM), TdT+ leukemic cells (N = 5) were sensitive to the cytotoxic effect of 3′-dA, whereas TdT- (N = 6) cells were not. A high level of 3′-dA-5′-triphosphate (3′-dATP) formation was detected in TdT+ NALM-6 cells (67 pmol/106 cells) and TdT- K562 cells (49 pmol/106 cells) when cultured with 1 μM [3′-3H]-labeled 3′-dA. A substantial level of 3′-dATP was detected in TdT- HUT-102 cells (27 pmol/106 cells), whereas the level of 3′-dATP in TdT+ MOLT-4 cells was low (0.3 pmol/106 cells). The mean IC50 values of 3′-dA against phytohemagglutinin (PHA)-activated and resting peripheral blood mononuclear cells (PBM) (N = 5) were 8 and 32 μM, resp. There was a modest level of 3′-dATP (7 pmol/106 cells) in PHA-PBM, whereas a lower level of 3′-dATP was detected in resting PBM (2.5 pmol/106 cells). These data suggest that the presence of 3′-dATP is not sufficient for the antileukemic effect of 3′-dA, but that TdT positivity is essential, and that PBM are significantly less sensitive to the cytotoxicity of 3′-dA in vitro. Further development of 3′-dA as a potential antileukemic agent to treat patients with TdT+ leukemia is warranted. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Related Products of 13146-72-0).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. THF can also be synthesized by catalytic hydrogenation of furan. This allows certain sugars to be converted to THF via acid-catalyzed digestion to furfural and decarbonylation to furan, although this method is not widely practiced. THF is thus derivable from renewable resources.Related Products of 13146-72-0

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Cordycepin and pentostatin biosynthesis gene identified through transcriptome and proteomics analysis of Cordyceps kyushuensis Kob was written by Zhao, Xuan; Zhang, Guoying; Li, Caiyi; Ling, Jianya. And the article was included in Microbiological Research on January 31,2019.Computed Properties of C10H12N4O4  The following contents are mentioned in the article:

Cordyceps kyushuensis is the only species of cordyceps growing on the larvae of Clanis bilineata Walker, and has been demonstrated that there are lots of pharmacol. components including cordycepin. Cordycepin shows lots of pharmacol. action but it could be converted to 3′-deoxyinosine by adenosine deaminase in vivo, which weakens the efficiency of cordycepin. That pentostatin, which has been reported to inhibit adenosine deaminase, combining cordycepin could enhance the efficiency of cordycepin in vivo. During transcriptome and proteomics anal. of Cordyceps kyushuensis, a single gene cluster including four genes we named ck1-ck4 which can synthesis both cordycepin and pentostatin has been identified using BLAST. Meanwhile, KEGG, KOG, GO anal. and differentially expressed genes were analyzed in transcriptome and proteomics. This study first sequenced transcriptome and proteomics of C. kyushuensis, and demonstrated that there is a single gene cluster related to biosynthesis of cordycepin and pentostatin, which can be employed to improve the yield of cordycepin and find more functional proteins. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Computed Properties of C10H12N4O4 ).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.Computed Properties of C10H12N4O4 

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Nucleosides and nucleotides. 143. Synthesis of 5-amino-4-imidazolecarboxamide (AICA) deoxyribosides from deoxyinosines and their conversion into 3-deazapurine derivatives was written by Minakawa, Noriaki; Sasabuchi, Yoshimasa; Kiyosue, Arihiro; Kojima, Naoshi; Matsuda, Akira. And the article was included in Chemical & Pharmaceutical Bulletin on February 29,1996.Reference of 13146-72-0 The following contents are mentioned in the article:

An efficient and large scale chem. synthesis of 5-aminoimidazole-4-carboxamide (AICA) deoxyribonucleosides I (R = OH, R1 = H; R = H, R1 = OH) is described. Treatment of 3′,5′-di-O-acetyl-N1-triphenylmethyl-2′-deoxyinosine with 5 N NaOH in EtOH, followed by anhydrous trifluoroacetic acid gave I (R = OH, R1 = H) in 59% yield from 2′-deoxyinosine. AICA 3′-deoxyriboside I (R = H, R1 = OH) was also obtained in a similar manner in 73% yield from 3′-deoxyinosine. Conversion of I into 3-deazapurines, e.g. II, is also described. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Reference of 13146-72-0).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. THF can also be synthesized by catalytic hydrogenation of furan. This allows certain sugars to be converted to THF via acid-catalyzed digestion to furfural and decarbonylation to furan, although this method is not widely practiced. THF is thus derivable from renewable resources.Reference of 13146-72-0

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Synergistic effect of 3′-deoxyadenosine N1-oxide and adenosine deaminase inhibitors on growth of Ehrlich ascites tumor cells in vivo was written by Svendsen, Karsten Ramloev; Overgaard-Hansen, Kay; Frederiksen, Sune. And the article was included in Cancer Chemotherapy and Pharmacology on February 29,1988.Product Details of 13146-72-0 The following contents are mentioned in the article:

The simultaneous administration of 3′-deoxyadenosine N’-oxide (3′-dANO) and the adenosine deaminase inhibitors erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) or 2′-deoxycoformycin (2′-dCF) to mice bearing Ehrlich ascites tumor cells resistant to 3′-dANO resulted in 80%-90% inhibition of tumor growth in vivo. 3′-DANO and 2′-dCF increased the survival time of tumor-bearing mice by a factor of 2. In vitro studies showed that the 3′-dANO resistant Ehrlich cells initiate the metabolism of 3′-dANO by a reduction to 3′-deoxyadenosine, which is converted primarily to 3′-deoxyinosine by adenosine deaminase and, to a small extent, phosphorylated to the cell toxic agent 3′-dATP. By the addition of EHNA or 2′-dCF, it was possible to block the formation of 3′-deoxyinosine; this stimulated the accumulation of 3′-dATP. Resistance to 3′-dANO in cell cultures was accompanied by changes in the following enzyme activities: reductase, adenosine kinase, and the adenosine deaminase. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Product Details of 13146-72-0).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.Product Details of 13146-72-0

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

C6-O-alkylated 7-deazainosine nucleoside analogs: Discovery of potent and selective anti-sleeping sickness agents was written by Hulpia, Fabian; Bouton, Jakob; Campagnaro, Gustavo D.; Alfayez, Ibrahim A.; Mabille, Dorien; Maes, Louis; de Koning, Harry P.; Caljon, Guy; Van Calenbergh, Serge. And the article was included in European Journal of Medicinal Chemistry on February 15,2020.Safety of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol The following contents are mentioned in the article:

African trypanosomiasis, a deadly infectious disease caused by the protozoan Trypanosoma brucei spp., is spread to new hosts by bites of infected tsetse flies. Currently approved therapies all have their specific drawbacks, prompting a search for novel therapeutic agents. T. brucei lacks the enzymes necessary to forge the purine ring from amino acid precursors, rendering them dependent on the uptake and interconversion of host purines. This dependency renders analogs of purines and corresponding nucleosides an interesting source of potential anti-T. brucei agents. In this study, we synthesized and evaluated a series of 7-substituted 7-deazainosine derivatives and found that 6-O-alkylated analogs in particular showed highly promising in vitro activity with EC50 values in the mid-nanomolar range. SAR investigation of the O-alkyl chain showed that antitrypanosomal activity increased, and also cytotoxicity, with alkyl chain length, at least in the linear alkyl chain series. However, this could be attenuated by introducing a terminal branch point, resulting in the highly potent and selective analogs,, e.g. I. No resistance related to transporter-mediated uptake could be identified, earmarking several of these analogs for further in vivo follow-up studies. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Safety of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.Safety of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Synthesis of 2′,3′-dideoxypurinenucleosides via the palladium catalyzed reduction of 9-(2,5-di-O-acetyl-3-bromo-3-deoxy-β-D-xylofuranosyl)purine derivatives was written by Shiragami, Hiroshi; Amino, Yusuke; Honda, Yutaka; Arai, Masayuki; Tanaka, Yasuhiro; Iwagami, Hisao; Yukawa, Toshihide; Izawa, Kunisuke. And the article was included in Nucleosides & Nucleotides on March 31,1996.Safety of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol The following contents are mentioned in the article:

Practical method to produce 2′,3′-dideoxypurinenucleosides from 9-(2,5-di-O-acetyl-3-bromo-3-deoxy-β-D-xylofuranosyl)purines (I; R1 = NH2, OH, R2 = H; R1 = OH, R2 = NHAc) was developed. High ratio of 2′,3′-dideoxynucleoside to 3′-deoxyribonucleoside was obtained by selecting the reaction conditions (solvent, pH and/or base), or changing 2′-acyloxy leaving group. The reaction mechanism was studied by deuteration experiments of I (R1 = NH2, R2 = H) and 1-(3,5-di-O-acetyl-2-bromo-2-deoxy-β-D-ribofuranosyl)thymine (II). This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Safety of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Safety of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Characterization of nucleoside phosphotransferase from Leishmania tropica was written by Shin, Il-Shik; Wataya, Yusuke. And the article was included in Nucleosides & Nucleotides on April 30,1995.Application In Synthesis of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol The following contents are mentioned in the article:

Nucleoside phosphotransferase, a unique purine salvage enzyme, was partially purified from L. tropica. The purified preparation was nucleosidase-free. With this enzyme preparation, phosphorylation of 14 nucleosides involving 5 antileishmanial purine nucleoside analogs was investigated. Apparent Km values of the enzyme for 10 purine nucleosides were in the range of 5.7-8.4 μM, and those for 4 natural pyrimidine nucleosides were in the range of 14.0-16.9 μM. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Application In Synthesis of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. THF can also be synthesized by catalytic hydrogenation of furan. This allows certain sugars to be converted to THF via acid-catalyzed digestion to furfural and decarbonylation to furan, although this method is not widely practiced. THF is thus derivable from renewable resources.Application In Synthesis of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0