Category: 13146-72-0

THE SYNTHESIS OF ANALOGS OF THE AMINONUCLEOSIDE FROM PUROMYCIN: 3′-AMINO-3′-DEOXYINOSINE AND 2,3′-DIAMINO-3′-DEOXYADENOSINE. was written by GOLDMAN, L; MARSICO, J W; WEISS, M J. And the article was included in Journal of medicinal chemistry in 1963.Safety of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol The following contents are mentioned in the article:

There is no abstract available for this document. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Safety of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.Safety of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Quantitative determination of Trypanosoma cruzi growth inside host cells in vitro and effect of allopurinol was written by Aoki, Takashi; Nakajima-Shimada, Junko; Hirota, Yumiko. And the article was included in Advances in Experimental Medicine and Biology in 1994.Application In Synthesis of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol The following contents are mentioned in the article:

We have constructed an in vitro culture system of host cells infected with T. cruzi for the quant. determination of time course of parasite growth. This system has enables us to test allopurinol and other agents for their efficacies in inhibiting the parasite growth inside the host cells. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Application In Synthesis of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.Application In Synthesis of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Cytotoxic compounds against cancer cells from Bombyx mori inoculated with Cordyceps militaris was written by Qiu, Weitao; Wu, Jing; Choi, Jae-Hoon; Hirai, Hirofumi; Nishida, Hiroshi; Kawagishi, Hirokazu. And the article was included in Bioscience, Biotechnology, and Biochemistry in 2017.Quality Control of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol The following contents are mentioned in the article:

Two compounds, 3′-deoxyinosine and cordycepin, were isolated from Bombyx mori inoculated with Cordyceps militaris. In the bioassay examining cytotoxicity against cancer cells, both compounds showed toxicity against A549, PANC-1, and MCF-7 cancer cells. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Quality Control of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.Quality Control of 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Human erythrocytic purine nucleoside phosphorylase: reaction with sugar-modified nucleoside substrates was written by Stoeckler, Johanna D.; Cambor, Carolyn; Parks, Robert E. Jr.. And the article was included in Biochemistry in 1980.Related Products of 13146-72-0 The following contents are mentioned in the article:

The kinetic parameters (Km and Vmax) of sugar-modified analogs of inosine and guanosine were determined with human erythrocyte purine nucleoside phosphorylase (I). Steric alterations at the 2′ and 3′ positions greatly lessened or abolished substrate activity. However, the 5′-deoxy- and 2′,5′-dideoxy-β-D-ribofuranosyl and the α-L-lyxosyl analogs were good substrates, indicating that the 5′-hydroxyl and the orientation of the 5′-hydroxymethyl group are not important for binding. The sugar phosphate analog, 5-doxyribose 1-phosphate, was synthesized from 5′-deoxyinosine with immobilized I, and its presence was verified by using it in the enzymic synthesis of 5′-deoxyguanosine. The adenosine versions of the 5′-modified analogs were also found to react with adenosine deaminase, albeit at <1% of Vmax. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Related Products of 13146-72-0).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.Related Products of 13146-72-0

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Radical dehalogenation and purine nucleoside phosphorylase E. coli: how does an admixture of 2′′,3′′-anhydroinosinehinder 2-fluoro-cordycepin synthesis was written by Kayushin, Alexey L.; Tokunova, Julia A.; Fateev, Ilja V.; Arnautova, Alexandra O.; Berzina, Maria Ya.; Paramonov, Alexander S.; Lutonina, Olga I.; Dorofeeva, Elena V.; Antonov, Konstantin V.; Esipov, Roman S.; Mikhailopulo, Igor A.; Miroshnikov, Anatoly I.; Konstantinova, Irina D.. And the article was included in Biomolecules in 2021.Reference of 13146-72-0 The following contents are mentioned in the article:

During the preparative synthesis of 2-fluorocordycepin from 2-fluoroadenosine and 3′′-deoxyinosine catalyzed by E. coli purine nucleoside phosphorylase, a slowdown of the reaction and decrease of yield down to 5% were encountered. An unknown nucleoside was found in the reaction mixture and its structure was established. This nucleoside is formed from the admixture of 2′′,3′′-anhydroinosine, a byproduct in the preparation of 3-′′deoxyinosine. Moreover, 2′′,3′′-anhydroinosine forms during radical dehalogenation of 9-(2′′,5′′-di-O-acetyl-3′′-bromo-3′′-deoxyxylofuranosyl)hypoxanthine, a precursor of 3′′-deoxyinosine in chem. synthesis. The products of 2′′,3′′-anhydroinosine hydrolysis inhibit the formation of 1-phospho-3-deoxyribose during the synthesis of 2-fluorocordycepin. The progress of 2′′,3′′-anhydroinosine hydrolysis was investigated. The reactions were performed in D2O instead of H2O; this allowed accumulating intermediate substances in sufficient quantities. Two intermediates were isolated and their structures were confirmed by mass and NMR spectroscopy. A mechanism of 2′′,3′′-anhydroinosine hydrolysis in D2O is fully determined for the first time. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Reference of 13146-72-0).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. Tetrahydrofurans and furans are important oxygen-containing heterocycles that often exhibit interesting properties for biological applications or applications in the cosmetic industry. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.Reference of 13146-72-0

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Thyroid purine nucleoside phosphorylase. II. Kinetic model by alternate substrate and inhibition studies was written by Carlson, Jeffrey D.; Fischer, Allan G.. And the article was included in Biochimica et Biophysica Acta, Enzymology in 1979.Related Products of 13146-72-0 The following contents are mentioned in the article:

Nucleoside analog inhibition studies were conducted on thyroidal purine nucleoside phosphorylase which catalyzed an ordered bi-bi-type mechanism in which the 1st substrate is inorganic phosphate and the last product is ribose 1-phosphate. Heterocyclic- and carbohydrate-modified nucleoside inhibitors demonstrated mixed-type inhibition, suggesting that such analogs show an affinity (Ki) for the free enzyme. A kinetic model is proposed which supports the observed inhibition patterns. These studies, together with alternate substrate studies, indicated that nucleoside binding requires a functional group capable of H bonding at the 6 position of the purine ring and that the orientation of the bound substrate may be syn. Proper geometry of the phosphate is dependent on the 3′ substituent being oriented below the furanose ring. The 5′-OH group is required for substrate activity. The proposed rate-limiting step of the phosphorylase mechanism is the enzymic protonation of the N-7 position of the nucleoside. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Related Products of 13146-72-0).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.Related Products of 13146-72-0

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Hypoxanthine nucleoside counterparts of the antibiotic, cordycepin was written by Nair, Vasu; Lyons, Arthur G.. And the article was included in Tetrahedron in 1990.Related Products of 13146-72-0 The following contents are mentioned in the article:

Analogs I (R = iodo, CH2CH:CH2, CH:CH2, CHO, CH2COMe, CN) of 3′-deoxyinosine, although of potential RNA antiviral interest, are virtually unknown. This paper reports on approaches to the synthesis of base-modified hypoxanthine 3′-deoxynucleosides. All of the target compounds are new and contain functionality at the 2-position that can be further elaborated for the synthesis of a variety of other novel analogs of 3′-deoxyinosine. Intact natural guanosine was used as the precursor and the key transformations utilized were regioselective bissilylation, thermal radical deoxygenation, regiospecific radical halogenation, metal-mediated functionalization, and selective ozonolysis. The synthetic approaches described have considerable generality in terms of entry to novel analogs of 3′-deoxyinosine. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Related Products of 13146-72-0).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. Oxidations have also proved to be valuable and efficient approaches to chiral tetrahydrofuran derivatives.Related Products of 13146-72-0

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Synthesis of 2′- and 3′-deoxyinosines was written by Yamazaki, Akihiro; Akiyama, Masao; Kumashiro, Izumi; Ikehara, Morio. And the article was included in Chemical & Pharmaceutical Bulletin in 1973.Formula: C10H12N4O4  The following contents are mentioned in the article:

Isopropylidenation of 8-mercaptoinosine with Me2C(OMe)2 in HClO4, followed by acetylation with Ac2O in pyridine, and then deisopropylidenation gave 5′-O-acetyl-8-mercaptoinosine (I). Tosylation of I, followed by treatment with NH3 in MeOH at 0° gave 18% 8,2′-anhydro-8-mercapto-9-β-D-arabino-(II) and 5.1% 8,3′-anhydro-8-mercapto-9-β-D-xylofuranosylhypoxanthine (III). Refluxing II and III with Raney Ni in aqueous solution gave 2′-deoxy- and 3′-deoxyinosine, resp. Treatment of II with POCl3 in (MeO)3PO, followed by hydrolysis gave 8.5% of the 5′-phosphate ester of II. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Formula: C10H12N4O4 ).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Formula: C10H12N4O4 

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Nucleosides of 2-azapurines. 7H-Imidazo[4,5-d]-1,2,3-triazines. 2 was written by Montgomery, John A.; Laseter, Anne G.; Shortnacy, Anita T.; Clayton, Sarah J.; Thomas, H. Jeanette. And the article was included in Journal of Medicinal Chemistry in 1975.Name: 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol The following contents are mentioned in the article:

A series of 7 title compounds, prepared by enzymic deamination of 2-azaadenine nucleosides or ring cleavage of hypoxanthine nucleosides followed by nitrosative ring closure to the 2-azahypoxanthine nucleosides, were tested in cultures of human epidermoid carcinoma Number 2 cells and sublines. 2-Azaadenosine (I) [146-94-1] was active against all cell lines except those lacking both adenosine kinase and hypoxanthine-guanine phosphoribosyltransferase. The 2-azaadenine nucleosides could be metabolized to the cytotoxic nucleotides by 2 pathways, but the 2-azahypoxanthine nucleosides activity resulted from cleavage to 2-azahypoxanthine. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Name: 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. Tetrahydrofuran (THF) is primarily used as a precursor to polymers including for surface coating, adhesives, and printing inks.Name: 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0

Anti-parasite activity of nucleoside analogs in Leishmania tropica promastigotes was written by Wataya, Y.; Hiraoka, O.; Sonobe, Y.; Yoshioka, A.; Matsuda, A.; Miyasaka, T.; Saneyoshi, M.; Ueda, T.. And the article was included in Nucleic Acids Symposium Series in 1984.COA of Formula: C10H12N4O4  The following contents are mentioned in the article:

Many nucleoside analogs were screened for antiprotozoal activity on L. tropica in an in vitro culture system. 3′-Deoxyinosine and several tubercidin derivatives were potent inhibitors for growth of the promastigote form of L. tropica. This compound was markedly less toxic towards mouse mammary tumor FM3A cells. 3′-Deoxyinosine is metabolized by Leishmania promastigote to give 3′-deoxyinosine-5′-monophosphate and 3′-deoxyadenosine(cordycepin)-5′-mono, di-, and triphosphates. This means that Leishmania can aminate the 6-position of 3′-deoxyinosine-5′-monophosphate, thereby converting it into a highly toxic compound This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0COA of Formula: C10H12N4O4 ).

9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.COA of Formula: C10H12N4O4 

13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0