Category: 13031-04-4

13031-04-4, Name is 4,4-Dimethyldihydrofuran-2,3-dione, belongs to Tetrahydrofurans compound, is a common compound. Formula: C6H8O3In an article, once mentioned the new application about 13031-04-4.

POLYFLUORINATED COMPOUNDS ACTING AS BRUTON TYROSINE KINASE INHIBITORS

Described herein is a novel series of multi-fluoro-substituted pyrazolopyrimidine compounds or salts thereof. These compounds are Bruton’s tyrosine kinase (BTK) inhibitors. These compounds may possess better BTK inhibition selectivity and pharmacokinetic properties. Disclosed herein are the synthesis methods of these compounds. Disclosed herein are novel synthesis methods of the multi-fluoro-substituted benzophenone and substituted phenoxy benzene. Also disclosed are pharmaceutical compositions comprising the BTK inhibitors described herein. The present invention also relates to pharmaceutical formulations comprising the compounds described herein as active ingredients. The present invention also includes the therapeutic methods by administering the BTK inhibitors and their formulations to treat and inhibit autoimmune disease, hypersensitivity disease, inflammatory diseases and cancer.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Recommanded Product: 4,4-Dimethyldihydrofuran-2,3-dione, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 13031-04-4, name is 4,4-Dimethyldihydrofuran-2,3-dione. In an article£¬Which mentioned a new discovery about 13031-04-4

Ketopantoyl-lactone reductase from Candida parapsilosis: Purification and characterization as a conjugated polyketone reductase

Ketopantoyl-lactone reductase (2-dehydropantoyl-lactone reductase, EC 1.1.1.168) was purified and crystallized from cells of Candida parapsilosis IFO 0708. The enzyme was found to be homogeneous on ultracentrifugation, high-performance gel-permeation liquid chromatography and SDS-polyacrylamide gel electophoresis. The relative molecular mass of the native and SDS-treated enzyme is approximately 40 000. The isoelectric point of the enzyme is 6.3. The enzyme was found to catalyze specifically the reduction of a variety of natural and unnatural polyketones and quinones other than ketopantoyl lactone in the presence of NADPH. Isatin and 5-methylisatin are rapidly reduced by the enzyme, the K(m) and V(max) values for isatin being 14 muM and 306 mumol/min per mg protein, respectively. Ketopantoyl lactone is also a good substrate (K(m) = 333 muM and V(max) = 481 mumol/min per mg protein). Reverse reaction was not detected with pantoyl lactone and NADP+. The enzyme is inhibited by quercetin, several polyketones and SH-reagents. 3,4-Dihydroxy-3-cyclobutene-1,2-dione, cyclohexenediol-1,2,3,4-tetraone and parabanic acid are uncompetitive inhibitors for the enzyme, the K(i) values being 1.4, 0.2 and 3140 muM, respectively, with isatin as substrate. Comparison of the enzyme with the conjugated polyketone reductase of Mucor ambiguus (S. Shimizu, H. Hattori, H. Ata and H. Yamada (1988) Eur. J. Biochem. 174, 37-44) and ketopantoyl-lactone reductase of Saccharomyces cerevisiae suggested that ketopantoyl-lactone reductase is a kind of conjugated polyketone reductase.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Application of 13031-04-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.13031-04-4, Name is 4,4-Dimethyldihydrofuran-2,3-dione, molecular formula is C6H8O3. In a Article£¬once mentioned of 13031-04-4

Synthesis of a New Chiral Pyrrolidine Ligand Bearing Two Different Types of Phosphino Groups and Their Effects on the Asymmetric Hydrogenation of Ketopantalolactone

The respective fuctions of the two phosphino groups of the pyrrolidinebisphosphine ligands in the asymmetric hydrogenation of ketopantalolactone were elucidated.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Application of 13031-04-4, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 13031-04-4, Name is 4,4-Dimethyldihydrofuran-2,3-dione, molecular formula is C6H8O3. In a Article£¬once mentioned of 13031-04-4

Enantioselective catalysis: Part 129. A new rhodium(I) complex with a mu2-H bridged Cp2WH2 ligand

The optically active complex {[(-)-diop]Rh(mu2-H)2WCp2}PF6 was prepared and characterized. In four different models of enantioselective catalysis the complex gave the same enantioselectivity as the catalysts [Rh(cod)Cl]2/(-)-diop and [Rh(cod)Cl]2/(-)-diop/Cp2WH2.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 13031-04-4. In my other articles, you can also check out more blogs about 13031-04-4

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Electric Literature of 13031-04-4, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 13031-04-4, Name is 4,4-Dimethyldihydrofuran-2,3-dione, molecular formula is C6H8O3. In a Article£¬once mentioned of 13031-04-4

Synthesis and application in enantioselective hydrogenation of new free and chromium complexed aminophosphine-phosphinite ligands

A straightforward synthesis of new free and Cr(CO)3 complexed AMPP ligands (4-7) is described starting from (S)-indoline-2-carboxylic acid. The ligands were applied successfully in the asymmetric hydrogenation of alpha-functionalized ketones i.e. a ketolactone 8, a ketoamide 9 and an aminoketone 10 leading to the corresponding optically active alcohols in 99, 97, and 99% ee respectively.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. name: 4,4-Dimethyldihydrofuran-2,3-dione, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 13031-04-4

Process for the asymmetric hydrogenation of carbonyl compounds obtained

The asymmetric hydrogenation of carbonyl compounds is carried out in the presence of at least one transition metal complex MZq(M=metal of group VIII of the Periodic Classication; Z=ligand selected among the atoms and the molecules which may complex the metal M; and q=degree of corrdination of M) and of at least one chiral phosphorous-containing ligand having formula (I), wherein R is hydrocarbonated radical (alkyl, cycloalkyl and aryl); R1 is H, hydrocarbonated radical or PR2 ; R2 is H or hydrocarbonated radical R3,R4, necessarily different, are H and optionally functionalized hydrocarbonated radicals; R5 and R6 are H and optionally functionalized hydrocarbonated radicals; one of the radicals R3 and R4 possibly carrying a function – OPR2 or NPR2, R5 and R6 being in this case H when R1 is PR2 ; R2 and R3 and the atoms of N and C which cary them respectively forming a heterocycle; or R2 and R5, the atoms of N and C which carry them respectively and the intermediate C atom possibly forming a heterocycle. STR1

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Synthetic Route of 13031-04-4, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 13031-04-4, Name is 4,4-Dimethyldihydrofuran-2,3-dione,introducing its new discovery.

Process for manufacturing a diketone

A process for producing dihydro-4,4-dimethyl-2,3-furandione by oxidizing dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone with a solid alkali metal hypochlorite or alkaline earth metal hypochlorite in an organic phase is disclosed.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 13031-04-4, name is 4,4-Dimethyldihydrofuran-2,3-dione, introducing its new discovery. Quality Control of 4,4-Dimethyldihydrofuran-2,3-dione

A novel class of fluorinated cinchona alkaloids as surface modifiers for the enantioselective heterogeneous hydrogenation of alpha-ketoesters

Novel C-9 fluorinated cinchona alkaloid derivatives were investigated as chiral surface modifiers for the platinum-catalyzed asymmetric heterogeneous hydrogenation of alpha-ketoesters. Enantioselectivities approaching those observed with the parent alkaloids were obtained, and direct comparison with conformationally labile deoxycinchonidine confirmed that the C-9 fluorine atom is important for performance. In this study, the 9-fluoro derivative of cinchonidine was shown to effect the reduction of ketopantolactone to (R)-pantolactone in quantitative yield with good levels of enantioinduction (57% ee) providing preliminary validation for this novel class of surface modifiers.

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Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: 4,4-Dimethyldihydrofuran-2,3-dione, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 13031-04-4, Name is 4,4-Dimethyldihydrofuran-2,3-dione, molecular formula is C6H8O3

Chiral imidazolidinone and proline-derived surface modifiers for the Pt-catalysed asymmetric hydrogenation of activated ketones

A series of imidazolidinone and proline derivatives have been synthesised and tested with regard to their suitability for the chiral modification of platinum used for the asymmetric hydrogenation of activated ketones. Hydrogenations of ketopantolactone (KPL), methyl benzoylformate (MBF) and trifluoroacetophenone (TFAP) performed at low hydrogen pressures (1 and 10 bar) were selected as test reactions. With some of these synthethic modifiers, encouraging levels of enantioselectivity were achieved (up to 73.5:26.5 e.r.) without optimisation of the reaction conditions. Moreover, performance enhancement of l-proline derived-modifiers, as a consequence of molecular editing with fluorine, was found to be significant (OH ? F, Deltaee up to 23%) contributing to the growing interest in modulating catalyst performance by fluorine introduction.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. name: 4,4-Dimethyldihydrofuran-2,3-dione, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 13031-04-4, in my other articles.

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Related Products of 13031-04-4, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 13031-04-4, molcular formula is C6H8O3, introducing its new discovery.

Asymmetric Reduction of Ketopantolactone by Baker’s Yeast

Enantioselectivity in the yeast reduction of ketopantolactone has been improved by addition of beta-cyclodextrin to the reaction mixture.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 13031-04-4 is helpful to your research. Related Products of 13031-04-4

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem