Category: 118399-28-3

118399-28-3, (R)-Benzyl (5-oxotetrahydrofuran-3-yl)carbamate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(R)-Benzyl 5-oxotetrahydrofuran-3-ylcarbamate (INTERMEDIATE 3, 27.0 g, 114.78 mmol) was dissolved in methanol (75 ml) and triethylamine (75 ml) was added at room temperature. The resulting mixture was allowed to stir overnight at this temperature. The mixture was concentrated in vacuo to provide the title product. This material was used to prepare INTERMEDIATE 5 without further purification.1H NMR (300 MHz, CHLOROFORM-d) delta ppm 2.67 (d, 2H) 3.60-3.72 (m, 3H) 3.70-3.78 (m, 1H) 4.00-4.15 (m, 2H) 5.03-5.18 (m, 2H) 5.52 (br. s., 1H) 7.28-7.42 (m, 5H).

118399-28-3, 118399-28-3 (R)-Benzyl (5-oxotetrahydrofuran-3-yl)carbamate 697924, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; US2012/35134; (2012); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

118399-28-3, (R)-Benzyl (5-oxotetrahydrofuran-3-yl)carbamate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(R)-Benzyl 5 -oxo-tetrahydrofuran-3 -ylcarbamate (24 g, 0.1 mol) was added to the solution ofMe2NH (45 g, 1 mol) in CH2Cl2 (500 ml). The mixture was stirred overnight. The solid was collected by filtration. Toluene (500 mL) was added to dissolve the solid, followed by (PhS)2 (32.7 g, 0.15 mol) and Bu3P (40 g, 0.2 mol). The mixture was heated to 80C and stirred for 18 h. The solvent was removed in vacuo. The residue was subjected to flash column chromatography on silica gel eluting with 50% EtO Ac/petroleum ether to provide 0123 (13.4 g, 35.3%). LC-MS: 373 [M+l]+. 1H NMR (CDCl3):delta 2.46 (m, 1H), 2.82 (s, 3H), 2.84 (s, 3H), 2.88 (m, 1H), 3.20 (m, 1H), 3.33 (m, 1H), 4.13 (m, 1H), 5.07 (s, 2H), 6.30 (d, J= 9.0 Hz, 1H), 7.15 (m, 1H), 7.32 (m, 9H).

118399-28-3, The synthetic route of 118399-28-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CURIS, INC.; WO2009/36035; (2009); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118399-28-3,(R)-Benzyl (5-oxotetrahydrofuran-3-yl)carbamate,as a common compound, the synthetic route is as follows.

4. Synthesis of intermediate 5a (0359) Exact Mass: 391.25 (0360) (0361) 5a [00127] To the solution of intermediate 4 (4.8 g, 20.4 mmol) in THF (80 mL) was added a (3.2 g, 20.4 mmol), and the solution was stirred at room temperature overnight. After completion of the reaction, the solvent was removed in vacuo to afford intermediate 5a (7.2 g, 100%) as yellow oil, which was used in the next reaction without any further purification., 118399-28-3

As the paragraph descriping shows that 118399-28-3 is playing an increasingly important role.

Reference£º
Patent; MERRIMACK PHARMACEUTICALS, INC.; DRUMMOND, Daryl, C.; GENG, Bolin; KIRPOTIN, Dmitri, B.; TIPPARAJU, Suresh, K.; KOSHKARYEV, Alexander; (125 pag.)WO2017/123616; (2017); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

118399-28-3, (R)-Benzyl (5-oxotetrahydrofuran-3-yl)carbamate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of intermediate d (27g,115mmol) and morpholine (2Og, 230 mmol) in 200 mL of dioxane was stirred at 70 0C for 18 hours and concentrated, EtOAc (500ml) was added and washed with brine, dried over Na2SO4 and concentrated to afford the product e as an oil, which was used for the next step without further purification (3 Ig, 84%). MS (ESI) m/e (M+H+):323; 1H-NMR (CDCl3, 400 MHz): delta 7.38-7.31 (m, 5H), 5.85 (m, IH), 5.12 (br s, 2H), 3.92 (m, IH), 3.71-3.49 (m, 10H), 2.91 (m, IH), 2.50 (m, IH).

118399-28-3, 118399-28-3 (R)-Benzyl (5-oxotetrahydrofuran-3-yl)carbamate 697924, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; GENENTECH, INC.; WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH; WO2008/61208; (2008); A2;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118399-28-3,(R)-Benzyl (5-oxotetrahydrofuran-3-yl)carbamate,as a common compound, the synthetic route is as follows.

Compound 0101 (24 g, 0.1 mol) was added to the solution OfMe2NH (45 g, 1 mol) in CH2Cl2 (500 ml). The mixture was stirred overnight. The solid was collected by filtration. Toluene (500 mL) was added to dissolve the solid, followed by (PhS)2 (32.7 g, 0.15 mol) and Bu3P (40 g, 0.2 mol). The mixture was heated to 8O0C and stirred for 18 h. The solvent was removed in vacuo. The residue was subjected to flash column chromatography on silica gel eluting with 50% EtO Ac/petroleum ether to provide 0208 (13.4 g, 35.3%). LC- MS: 373 [M+l]+. 1H NMR (CDCl3):^ 2.46 (m, IH), 2.82 (s, 3H), 2.84 (s, 3H), 2.88 (m, IH), 3.20 (m, IH), 3.33 (m, IH), 4.13 (m, IH), 5.07 (s, 2H), 6.30 (d, J= 9.0 Hz, IH), 7.15 (m, IH), 7.32 (m, 9H)., 118399-28-3

As the paragraph descriping shows that 118399-28-3 is playing an increasingly important role.

Reference£º
Patent; CURIS, INC.; WO2009/36051; (2009); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118399-28-3,(R)-Benzyl (5-oxotetrahydrofuran-3-yl)carbamate,as a common compound, the synthetic route is as follows.

12. Synthesis of intermediate 5c (0389) Exact Mass: 363.22 (0390) (0391) 4 5c (0392) [00135] To the solution of intermediate 4 (6.5 g, 27.7 mmol) in THF (100 mL) was added intermediate c (3.6 g, 27.7 mmol), and the solution was stirred at room temperature overnight. After completion of the reaction, the solvent was removed in vacuo, the residue was purified by chromatography column (PE EA = 3/1) to afford intermediate 5c (7.2 g, 72%) as yellow oil. 3, 118399-28-3

The synthetic route of 118399-28-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERRIMACK PHARMACEUTICALS, INC.; DRUMMOND, Daryl, C.; GENG, Bolin; KIRPOTIN, Dmitri, B.; TIPPARAJU, Suresh, K.; KOSHKARYEV, Alexander; (125 pag.)WO2017/123616; (2017); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

118399-28-3, (R)-Benzyl (5-oxotetrahydrofuran-3-yl)carbamate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

solution of compound e (30 g, 127 mmol) and Me2NH (excess) in 200 ml of dioxane was stirred at 0 0C for 24 hours and concentrated, EtOAc (500 ml) was added and washed with brine, dried over Na2SO4 and concentrared. The resulting oil of e was prepared for the next step without further purification (32 g, 90%). MS (ESI) m/e (M+H+): 281; 1H-NMR (CDCl3, 400 MHz): delta 135-121 (m, 5H), 5.89 (m, IH), 5.09 (s, 2H), 3.97 (m, IH), 3.78-3.67 (m, 2H), 2.77-2.62 (m, 2H).

118399-28-3, As the paragraph descriping shows that 118399-28-3 is playing an increasingly important role.

Reference£º
Patent; GENENTECH, INC.; WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH; WO2008/61208; (2008); A2;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem