Category: 10374-51-3

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10374-51-3,5-(Hydroxymethyl)dihydrofuran-2(3H)-one,as a common compound, the synthetic route is as follows.

Example 1 (S)-gamma-Pivaloyloxymethyl-gamma-butyrolactone (V) To a solution of (S)-gamma-hydroxymethyl-gamma-butyrolactone1 Prepared according to the literature procedure: M. Taninguchi, K. Koga, S. Yamada, Tetrahedron, 30 , 3547 (1974).1(40 g, 0.34M) in pyridine (200 mL) was added pivaloyl chloride (46 g, 0.38M) and the mixture was heated at 50C for 5 h under nitrogen. The reaction was cooled to room temperature and MeOH (50 mL) was added. The mixture was then concentrated in vacuo, taken up in CH2Cl2-water. The CH2Cl2 was washed with water, 30% H3PO4, brine, and dried over MgSO4. After removal of the solvent under reduced pressure, the residual oil was chromatographed on silica gel using CH2Cl2 as eluent to give 2 (48 g, 70%) as a colorless oil: 1H NMR (CDCl3) delta 1.15 (s, 9H), 1.9-2.6 (m, 4H), 4.09 (dd, J=4.8, 12.3 Hz, 1H), 2.29 (dd, J=3.3, 12.3 Hz, 1H), 4.7-4.75 (m, 1H)., 10374-51-3

As the paragraph descriping shows that 10374-51-3 is playing an increasingly important role.

Reference£º
Patent; Bristol-Myers Squibb Company; EP502447; (1992); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

10374-51-3, 5-(Hydroxymethyl)dihydrofuran-2(3H)-one is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

10374-51-3, (3) at room temperature,To a 500 mL four-necked flask was added 15 g of compound 3,14.4 g of TEA and 150 mL of DCM.Nitrogen replacement three times, nitrogen protection,Cooling to -30 ,16.3 g of methanesulfonyl chloride (MsCl) was slowly added to the system,Warming significantly, temperature control -40 drop.After 10 min, the drop was completed and the incubation reaction was carried out for 10 min.After returning to room temperature reaction.To the system by adding 200mL of water quenching, the system directly liquid,The aqueous phase was extracted with DCM (50 mL * 3), the organic phases were combined, dried,The water was concentrated to give a total of 27.5 g of a brown oily liquid (Compound 4).

10374-51-3 5-(Hydroxymethyl)dihydrofuran-2(3H)-one 98431, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Si Fenke Si Pharmaceutical Research And Development (Tianjin) Co., Ltd.; Yao Qingjia; Wu Simin; Xu Yangjun; (6 pag.)CN106748972; (2017); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

10374-51-3, 5-(Hydroxymethyl)dihydrofuran-2(3H)-one is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,10374-51-3

A stirrer, a thermometer,Into a 50 mL reactor equipped with a gas inlet tube,1.8 g (0.0155 mol) of gamma-hydroxymethyl-gamma-butyrolactone, 1.4 g(0.0171 mol) of pyridine,5.6 g of toluene was charged, 4.9 g (0.0166 mol) of stearoyl chloride was dropped into a nitrogen atmosphere, and the reaction was carried out at 25 C. for 2 hours.The obtained reaction solution was washed with water, washed with an acid, deacidified and washed with water, and the toluene layer was concentrated to obtain 4.3 g of the desired compound as a solid.The solid obtained was a white solid (Infrared absorption spectrum (KBr tablet method): 2924, 2855, 1775, 1731, 1153 cm -1). The structure of the compound was confirmed by 1 H-NMR spectrum and it was confirmed to be a compound represented by the following structural formula (Attribution number of 1 H-NMR spectrum in the formula, and its assignment is shown in Table 1 ).

As the paragraph descriping shows that 10374-51-3 is playing an increasingly important role.

Reference£º
Patent; NIPPON FINE CHEMICAL CO LTD; HASHIMOTO, AKIHIRO; KODERA, HIROKI; KATSUMATA, YUKI; SHAKUSHI, RISA; OHASHI, YUKIHIRO; (42 pag.)JP6039336; (2016); B2;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

10374-51-3, 5-(Hydroxymethyl)dihydrofuran-2(3H)-one is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2.1 mL of trifluoromethanesulfonic acid was added to a solution of 13.8 g of 5-(hydroxymethyl)oxolane-2-one and 19.0 g of 2,4,6-tris(benzyloxy)-1,3,5-triazine in 150 mL of dioxane at a temperature of 5 C. to 10 C., and the obtained mixture was then stirred at room temperature for 5 hours. Thereafter, the reaction mixture was added to a mixture of 400 mL of ethyl acetate and 300 mL of a saturated sodium hydrogen carbonate aqueous solution. The organic layer was fractionated, and it was successively washed with 300 mL of water and 300 mL of a saturated sodium chloride aqueous solution, and was then dried over anhydrous sodium sulfate. The solvent was distilled away under reduced pressure, and the obtained residue was then purified by silica gel column chromatography (ethyl acetate/hexane=2/3 to 1/1), so as to obtain 22.4 g of 5-((benzyloxy)methyl)oxolane-2-one in the form of a colorless oily product. 1H-NMR (CDCl3) delta value: 7.33-7.28 (5H, m), 4.68-4.61 (1H, m), 4.572 (1H, s), 4.566 (1H, s), 3.68 (1H, dd, J=10.8, 4.5 Hz), 3.58 (1H, dd, J=10.8, 4.2 Hz), 2.57-2.42 (2H, m), 2.35-2.06 (2H, m), 10374-51-3

The synthetic route of 10374-51-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; FUJIFILM CORPORATION; NAKAMURA, Kouki; SHIMAMURA, Satoshi; IMOTO, Junichi; TAKAHASHI, Motomasa; WATANABE, Katsuyuki; WADA, Kenji; FUJINO, Yuuta; MATSUMOTO, Takuya; TAKAHASHI, Makoto; OKADA, Hideki; YAMANE, Takehiro; ITO, Takayuki; US2015/152131; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

10374-51-3, 5-(Hydroxymethyl)dihydrofuran-2(3H)-one is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1 (S)- gamma -Pivaloyloxymethyl- gamma -butyrolactone (V) To a solution of (S)-gamma-hydroxymethyl-gamma-butyrolactone1 Prepared according to the literature procedure: M. Taninguchi, K. Koga, S. Yamada, Tetrahedron, 30 , 3547 (1974).1(40 g, 0.34M) in pyridine (200 mL) was added pivaloyl chloride (46 g, 0.38M) and the mixture was heated at 50C for 5 h under nitrogen. The reaction was cooled to room temperature and MeOH (50 mL) was added. The mixture was then concentrated in vacuo, taken up in CH2Cl2-water. The CH2Cl2 was washed with water, 30% H3PO4, brine, and dried over MgSO4. After removal of the solvent under reduced pressure, the residual oil was chromatographed on silica gel using CH2Cl2 as eluent to give 2 (48 g, 70%) as a colorless oil: 1H NMR (CDCl3) delta 1.15 (s, 9H), 1.9-2.6 (m, 4H), 4.09 (dd, J=4.8, 12.3 Hz, 1H), 2.29 (dd, J=3.3, 12.3 Hz, 1H), 4.7-4.75 (m, 1H)., 10374-51-3

10374-51-3 5-(Hydroxymethyl)dihydrofuran-2(3H)-one 98431, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Bristol-Myers Squibb Company; EP501511; (1992); A2;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem