Category: 1028-33-7

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Comparative Study, English Abstract, Article, Arzneimittel-Forschung called Absorption studies with purines. Part 2: In vitro determination with the Resomat II using the Dibbern method, Author is Heppt-Becker, I.; Schunack, W., which mentions a compound: 1028-33-7, SMILESS is CN1C=NC(N(C(N2CCCCCC)=O)C)=C1C2=O, Molecular C13H20N4O2, Safety of 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione.

By means of the Resomat II partition apparatus, the diffusion of 8 purines from artificial gastric or intestinal juice to artificial plasma across acetate and polyamide membranes was determined by the method of H. W. Dibbern and G. H. Scholz (1969), and the diffusion rate constants were calculated according to H. Stricker (1973). The drugs showed a proportional relation between diffusion rate and lipid solubility The effect of the different membranes on the model absorption results was studied, with and without applied alternating pressure. The results are compared with those of the Sartorius absorption model. Diffusion constants are given for each drug for absorption from gastric juice (pH 1.1) and intestinal juice (pH 7.0), and relations with drug structure are considered. The compounds studied were 1-hexyltheobromine [1028-33-7], 8-chlorotheophylline [85-18-7], theophylline (I) [58-55-9], caffeine (II) [58-08-2], pentoxifylline [6493-05-6], theobromine [83-67-0], proxyphylline [603-00-9], and diprophylline [479-18-5].

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Forensic Science International called Positive and negative ion mass spectrometry of ten xanthine derivatives and their rapid clean-up with Sep-Pak C18 cartridges from biological samples, Author is Kumazawa, Takeshi; Sato, Keizo; Seno, Hiroshi; Ishii, Akira; Suzuki, Osamu, which mentions a compound: 1028-33-7, SMILESS is CN1C=NC(N(C(N2CCCCCC)=O)C)=C1C2=O, Molecular C13H20N4O2, Formula: C13H20N4O2.

Pos. ion electron impact (PIEI), pos. ion chem. ionization (PICI) and neg. ion chem. ionization (NICI) mass spectra are presented for ten xanthine derivatives; and each fragmentation pathway has been analyzed. In the PIEI mode, mol. ions were generally intense and constituted base peaks in five compounds Peaks at m/z 42 (NCO) appeared in all compounds; fragment cations at m/z 55, 68 (or 67) and 82 were observed in many compounds In the PICI mode, all drugs showed intense [M+H]+ quasi-mol. peaks together with small peaks at m/z M+C2H5 and M+C3H5; fragment peaks at m/z 44, 58, 72 and/or 84 (or 86) were also observed In the NICI mode, [M-H]- quasi-mol. peaks appeared in nine compounds and constituted base peaks in five compounds; adduct anions at m/z M+32 and/or M+C3H7, and fragment anions at m/z 42, 165 and/or 179 were also observed in many compounds Detection limits for total ion monitoring of the drugs in the PIEI, PICI and NICI modes were 2.2-10 ng, 11-28 ng and 7.8-14 ng on column, resp. Xanthine derivatives present in human plasma or urine could be rapidly extracted by use of Sep-Pak C18 cartridges with chloroform/methanol as elution solvent; recovery of the drugs from the plasma and urine was > 75%. They were also detected by capillary gas chromatog. (GC) with both flame ionization detection (FID); their limits were 1.6-8.3 ng on column.

If you want to learn more about this compound(1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione)Formula: C13H20N4O2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1028-33-7).

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Dagenais, M.; Pomier-Layrargues, G.; Rocheleau, B.; Giroux, L.; Huet, P. M. researched the compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione( cas:1028-33-7 ).Computed Properties of C13H20N4O2.They published the article 《Systemic and splanchnic hemodynamic effects of pentifylline in rats with portal hypertension》 about this compound( cas:1028-33-7 ) in Clinical Science. Keywords: pentifylline hemodynamics portal hypertension. We’ll tell you more about this compound (cas:1028-33-7).

The systemic and splanchnic hemodynamic effects of pentifylline (40 mg/kg body weight i.v.) were assessed in rats with portal hypertension associated either with CCl4-induced cirrhosis or portal vein ligation. Heparinized catheters were placed into the portal vein, inferior vena cava, aorta and left ventricle with exits from the neck. Hemodynamic studies were performed 4 h after consciousness was regained. Cardiac output and regional blood flows were measured using radiolabeled microspheres and the reference sample method in seven rats in each group; portal-systemic shunting was measured using microsphere injection in the ileo-colic vein in six rats in each group. Forty-five minutes after injection, pentifylline had no effect on mean arterial pressure, cardiac output, peripheral resistance, portal venous flow, hepatic artery flow or portal-systemic shunting in either group of rats with portal hypertension. The drug lowered portal pressure (-18%) in cirrhotic rats, but not in portal-vein-ligated rats. These data demonstrate that pentifylline lowers portal pressure in cirrhotic rats without affecting portal venous flow and portal-systemic shunting; this effect is possibly mediated by changes in intrahepatic resistance related to the effects of pentifylline on blood viscosity and/or on intrahepatic vasomotor tone.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem