Category: 1028-33-7

Stefanovich, V. published the article 《Effect of 3,7-dimethyl-1-(5-oxo-hexyl)xanthine and 1-hexyl-3,7-dimethyl xanthine on cyclic AMP phosphodiesterase of the human umbilical cord vessels》. Keywords: xanthine vasodilator phosphodiesterase inhibitor.They researched the compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione( cas:1028-33-7 ).Synthetic Route of C13H20N4O2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1028-33-7) here.

The vasoactive 3,7-dimethyl-1-(5-oxohexyl)xanthine (I) [6493-05-6] and 1-hexyl-3,7-dimethylxanthine (II) [1028-33-7] decreased cyclic AMP phosphodiesterase (PDE) [9036-21-9] activity in homogenates of arteries and veins of the human umbilical cord. II caused greater inhibition of arterial PDE than did I, but after 30 min perfusion of the arteries with either I or II, PDE inhibition by both xanthines was about equal, indicating that I penetrates the artery more than II. Thus, the vasodilating activity of I and II may be due to permeation of the vascular membrane and PDE inhibition, and then a consequent increase in cyclic AMP content.

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Bondar, V. S.; bolotov, V. V.; Mamina, Ye. A.; Stepanenko, V. I.; Stadnichenko, E. I. published the article 《Separation and identification of purine preparations in compounds by thin-layer chromatography》. Keywords: purine derivative TLC; chromatog purine derivative.They researched the compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione( cas:1028-33-7 ).Name: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1028-33-7) here.

System of solvents for separation of purine preparations on Silufol UF-254 and BETCX-plates were suggested. Sensitivity of identification for a number of reagent were established. The best sensitivity (1.5 μg) was observed for Dragendorff’s reagent.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Does oxypentifylline reduce the intensity of acute graft-versus-host disease following allogeneic bone marrow transplantation?》. Authors are Ghosh, K; Hutchinson, R M.The article about the compound:1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dionecas:1028-33-7,SMILESS:CN1C=NC(N(C(N2CCCCCC)=O)C)=C1C2=O).Formula: C13H20N4O2. Through the article, more information about this compound (cas:1028-33-7) is conveyed.

From 1988 to 1993, a retrospective analysis of the severity of acute graft-versus-host disease (GVHD) was carried out in two groups of patients undergoing allogeneic bone marrow transplantation for various haematological disorders. One group of 23 patients received oxypentifylline in a dose of 400 mg, 6 hourly, orally, day -10 to day +35 in addition to other standard management received by the control group of 20 patients. Acute GVHD was scored in each patient according to the Seattle criteria. Patients receiving oxypentifylline showed a lower GVHD score in each organ-specific area and this reached significance with the total GVHD score. A significantly smaller proportion of patients in the treatment group developed acute GVHD of grade 2 or more. It is concluded that oxypentifylline used in the present dosage reduces the intensity of acute GVHD following allogeneic bone marrow transplantation and is also well tolerated by the patient.

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SDS of cas: 1028-33-7. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, is researched, Molecular C13H20N4O2, CAS is 1028-33-7, about Predictable stereoselective and chemoselective hydroxylations and epoxidations with P450 3A4. Author is Larsen, Aaron T.; May, Erin M.; Auclair, Karine.

Enantioselective hydroxylation of one specific methylene in the presence of many similar groups is debatably the most challenging chem. transformation. Although chemists have recently made progress toward the hydroxylation of inactivated C-H bonds, enzymes such as P 450s (CYPs) remain unsurpassed in specificity and scope. The substrate promiscuity of many P 450s is desirable for synthetic applications; however, the inability to predict the products of these enzymic reactions is impeding advancement. We demonstrate here the utility of a chem. auxiliary to control the selectivity of CYP3A4 reactions. When linked to substrates, inexpensive, achiral theobromine directs the reaction to produce hydroxylation or epoxidation at the fourth carbon from the auxiliary with pro-R facial selectivity. This strategy provides a versatile yet controllable system for regio-, chemo-, and stereoselective oxidations at inactivated C-H bonds and demonstrates the utility of chem. auxiliaries to mediate the activity of highly promiscuous enzymes.

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Application In Synthesis of 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, is researched, Molecular C13H20N4O2, CAS is 1028-33-7, about Synthesis and Characterization of Novel β-Bis(N,N-diarylamino)-Substituted Porphyrin for Dye-Sensitized Solar Cells under 1 sun and Dim Light Conditions. Author is Reddy, Kamani Sudhir K.; Liu, Yu-Chieh; Chou, Hsien-Hsin; Kala, Kannankutty; Wei, Tzu-Chien; Yeh, Chen-Yu.

The authors synthesized a novel porphyrin dye named SK7, which contains two N,N-diarylamino moieties at two β-positions as electron-donating units and one carboxy phenylethynyl moiety at the meso-position as an electron-withdrawing, anchoring group. This novel dye was tested for the application in dye-sensitized solar cells. The light-harvesting behavior of SK7 and YD2 was studied using UV-visible absorption and d. functional calculation The electron transport properties at the TiO2/dye/electrolyte interface for SK7- and YD2-based devices were evaluated by electrochem. impedance spectroscopy. X-ray crystallog. characterization was conducted to understand the influence of two N,N-diarylamino units at two β-positions. The power conversion efficiencies of ∼6.54% under 1 sun illumination (AM 1.5 G) and ∼19.72% under a T5 light source were noted for the SK7 dye. The performance of SK7 is comparable to that of dye YD2, which contains only one N,N-diarylamino moiety at the meso-position (∼7.78 and 20.00% under 1 sun and T5 light, resp.).

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Recommanded Product: 1028-33-7. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, is researched, Molecular C13H20N4O2, CAS is 1028-33-7, about Effects of pentoxifylline, pentifylline and γ-interferon on proliferation, differentiation, and matrix synthesis of human renal fibroblasts. Author is Strutz, Frank; Heeg, Malte; Kochsiek, Tobias; Siemers, Gesa; Zeisberg, Michael; Muller, Gerhard A..

This study analyzed the potential antifibrotic effects of the title substances on human kidney fibroblasts in vitro. Primary renal fibroblasts were established from human kidney biopsies and were studied in addition to two renal fibroblast cell lines. The cells were first growth-arrested by withdrawal of fetal calf serum (FCS) and subsequently stimulated with 10% FCS in the presence of different concentrations of pentoxifylline (PTX), pentifylline (PTF), or γ-interferon (IFN-γ). PTX and PTF caused a concentration- and time-dependent inhibition of proliferation in all the fibroblast lines (maximum 78.9% at 500 μg PTX/mL). Conversely, IFN-γ had only modest effects on fibroblast proliferation. Northern blot hybridizations showed that basic fibroblast growth factor (FGF)-2 mRNA in fibroblasts was decreased by 73.7 and 91.5% by PTX (1000 μg/mL) and PTF (100 μg/mL), resp., whereas IFN-γ led to a reduction of 46.2% at 1000 U/mL, indicating that the inhibitory effects of all three substances may be mediated through inhibition of FGF-2 synthesis. No change in mRNA for transforming growth factor-1 was noted. Synthesis of cellular and secreted collagen type I was robustly inhibited by PTX and PTF, whereas IFN-γ exerted the strongest inhibitory effect on fibronectin synthesis and secretion. In addition, IFN-γ down-regulated the expression of α-smooth-muscle actin by 73.3% (at 1000 U/mL), whereas PTX and PTF caused a down-regulation of 49.7 and 80.0% (at 1000 and 100 μg/mL), resp. PTF was in all experiments about 10 times more potent than equimolar concentrations of PTX. Thus, PTX and PTF exerted robust inhibitory effects on fibroblast proliferation, extracellular matrix synthesis, and myofibroblast differentiation. Conversely, IFN-γ caused strong inhibition of fibronectin synthesis and α-smooth-muscle cell actin expression but had only weak inhibitory influences on fibroblast proliferation and collagen type I synthesis. The inhibitory effects of all three substances on proliferation may be mediated through inhibition of FGF-2 synthesis.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1028-33-7, is researched, SMILESS is CN1C=NC(N(C(N2CCCCCC)=O)C)=C1C2=O, Molecular C13H20N4O2Journal, Article, Pharmazie called Analysis of drug mixtures. VII. Gas chromatographic separation of some xanthine derivatives, Author is Reisch, Johannes; Walker, Hans, the main research direction is XANTHINES GAS CHROMATOG; GAS CHROMATOG XANTHINES; THEOBROMINES GAS CHROMATOG; CAFFEINES GAS CHROMATOG.Formula: C13H20N4O2.

cf. Deut. Apotheker-Ztg. 105, 575(1965); CA 63, 16129g. Such separations were successfully applied with modern apparatus using ballistic or linear temperature programming (PTGC) to the following compounds: caffeine, theobromine (I), theophylline (II), the 7-[2-hydroxyethyl] derivative of II, the 1-[2-hydroxypropyl] derivative of I, the 7-[N-methy-N-hydroxyethyl-3-amino-2-hydroxypropyl] derivative of II, the 7-[2,3-dihydroxypropyl] derivative of II, the 1-allyl derivative of I, the 7-2propynyl derivative of II, the 1-2-propynyl derivative of I, the 1-hexyl derivative of I and 8-chlorotheophylline. On a small scale, the method is used for analysis of tablets, etc., but on a larger scale with appropriate equipment, could be applied to the separation of xanthine derivatives from foods and drugs. Column packing was 1.5% SE30 on Chromosorb W, 6′ × 1/4″” column, injection port 300°, detector 350°, He flow 60 ml./min.

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Tetrahydrofuran – Wikipedia,
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Computed Properties of C13H20N4O2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, is researched, Molecular C13H20N4O2, CAS is 1028-33-7, about Inhibition of platelet adenosine cyclic 3′,5′-monophosphate phosphodiesterases by pentifylline.

Pentifylline (1-hexyl-3,7-dimethylxanthine)(I) [1028-33-7] inhibited the soluble and particulate cyclic AMP phosphodiesterase [9036-21-9] from bovine platelets. From dose-response curves the following I50 values were obtained: 2.0 × 10-3M for the soluble enzyme and 8.1 × 10-4M for the particulate enzyme. Noncompetitive inhibition was observed for both phosphodiesterases and the Ki values were 7.6 × 10-4M and 7.4 × 10-4M for the soluble and particulate enzyme, resp. It is concluded that the inhibition of platelet phosphodiesterase is a component of the therapeutic action of pentifylline.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Effects of xanthine derivatives on cerebral metabolism, published in 1972, which mentions a compound: 1028-33-7, Name is 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, Molecular C13H20N4O2, Recommanded Product: 1028-33-7.

In rats made hypoxic by exposure to simulated high altitude, the brain was studied electroencephalog. as a model of clin. brain senescence. Contrary to theophylline [58-55-9] and theobromine [83-67-0], 1-hexyl-3,7-dimethylxanthine (I) [1028-33-7] improved the brain nutritional state during hypoxia when injected (25 mg/kg) 20 min prior to exposure. This was due to an increased supply of glucose [50-99-7] to the brain, apparently as a consequence of a direct stimulatory action of I on glucose transport across the blood-brain barrier.

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Turcant, A.; Cailleux, P.; Allain, P. published the article 《Separation of xanthine derivatives by high-pressure liquid chromatography and application to plasma analysis》. Keywords: xanthine separation plasma liquid chromatog; high pressure liquid chromatog xanthine.They researched the compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione( cas:1028-33-7 ).Quality Control of 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1028-33-7) here.

High pressure liquid chromatog. (HPLC) methods were developed for separation and plasma anal. of 10 xanthine derivatives Separation was evaluated on a silica column and on 3 different reverse phase columns, with optimum conditions obtained on a C6 spherisorb column using isocratic elution with phosphate buffer 10-2 M, pH 2.7 – acetonitrile mixture (80/20/volume/volume). Determination of these xanthine derivatives in plasma for therapeutic control was studied.

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