A small discovery about 1028-33-7

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Inhibition of various cyclic AMP phosphodiesterases by pentifylline and theophylline》. Authors are Stefanovich, V.; Von Poelnitz, M.; Reiser, M..The article about the compound:1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dionecas:1028-33-7,SMILESS:CN1C=NC(N(C(N2CCCCCC)=O)C)=C1C2=O).Formula: C13H20N4O2. Through the article, more information about this compound (cas:1028-33-7) is conveyed.

The inhibiting effect of pentifylline (1-hexyl-3,7-dimethylxanthine) (I) and theophylline (II) was tested on 3′,5′-AMP-phosphodiesterase (III) of 7 organs of guinea pigs, of rat brain, and bovine heart. I was a better inhibitor than II of III of rat brain and bovine heart. The difference between the degrees of inhibition by I and II was largest in the case of III of rat brain. I inhibited III of bovine heart noncompetitively and II did so competitively. Serum albumin affected the I inhibition of bovine heart III more than it did the inhibition by II. II exhibited the highest effect on guinea pig heart III while I did so on III of brain.

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Let`s talk about compounds: 1028-33-7

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Some aspects of the pharmacological activity of a new theophyllinic: 1-hexyl-3,7-dimethylxanthine (SK-7), published in 1960, which mentions a compound: 1028-33-7, Name is 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, Molecular C13H20N4O2, Recommanded Product: 1028-33-7.

The vascular action of theophylline (I) and its derivatives and the lipotropic and antieholesterol (II) activity of I have been investigated. SK-7 reduced the amplitude of the cardiogram of isolated rabbit hearts to an extent roughly proportional to the dosage, but the effect was brief; only a dose of 500 γ of SK-7, after a brief period of inhibition, succeeded in restoring the amplitude of the tracing to a level slightly superior to that of the normal. While a dose of SK-7 of 1 mg./kg. body weight only slightly affected the arterial pressure of anesthetized dogs, a dose of 10 mg./kg. was definitely hypotensive, with a vasodilatory effect on the cerebral circulation. SK-7 increased the capacity of the vessels in the posterior portions of the rabbit and protected the rat against both gangrene in the tail and cyanosis. A protective influence of SK-7 against hyperlipide and hyper-II steatosis in the liver of rats has been demonstrated. Contrary to other derivatives of I, SK-7 has almost no effect on cardiac or coronary activity, and has a strong cerebral vasodilatory action. Its hypotensive and peripheral vasodilatory activities were typical of many xanthine compounds

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A small discovery about 1028-33-7

Compounds in my other articles are similar to this one(1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione)Formula: C13H20N4O2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Inhibition of various cyclic AMP phosphodiesterases by pentifylline and theophylline》. Authors are Stefanovich, V.; Von Poelnitz, M.; Reiser, M..The article about the compound:1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dionecas:1028-33-7,SMILESS:CN1C=NC(N(C(N2CCCCCC)=O)C)=C1C2=O).Formula: C13H20N4O2. Through the article, more information about this compound (cas:1028-33-7) is conveyed.

The inhibiting effect of pentifylline (1-hexyl-3,7-dimethylxanthine) (I) and theophylline (II) was tested on 3′,5′-AMP-phosphodiesterase (III) of 7 organs of guinea pigs, of rat brain, and bovine heart. I was a better inhibitor than II of III of rat brain and bovine heart. The difference between the degrees of inhibition by I and II was largest in the case of III of rat brain. I inhibited III of bovine heart noncompetitively and II did so competitively. Serum albumin affected the I inhibition of bovine heart III more than it did the inhibition by II. II exhibited the highest effect on guinea pig heart III while I did so on III of brain.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Let`s talk about compounds: 1028-33-7

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Some aspects of the pharmacological activity of a new theophyllinic: 1-hexyl-3,7-dimethylxanthine (SK-7), published in 1960, which mentions a compound: 1028-33-7, Name is 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, Molecular C13H20N4O2, Recommanded Product: 1028-33-7.

The vascular action of theophylline (I) and its derivatives and the lipotropic and antieholesterol (II) activity of I have been investigated. SK-7 reduced the amplitude of the cardiogram of isolated rabbit hearts to an extent roughly proportional to the dosage, but the effect was brief; only a dose of 500 γ of SK-7, after a brief period of inhibition, succeeded in restoring the amplitude of the tracing to a level slightly superior to that of the normal. While a dose of SK-7 of 1 mg./kg. body weight only slightly affected the arterial pressure of anesthetized dogs, a dose of 10 mg./kg. was definitely hypotensive, with a vasodilatory effect on the cerebral circulation. SK-7 increased the capacity of the vessels in the posterior portions of the rabbit and protected the rat against both gangrene in the tail and cyanosis. A protective influence of SK-7 against hyperlipide and hyper-II steatosis in the liver of rats has been demonstrated. Contrary to other derivatives of I, SK-7 has almost no effect on cardiac or coronary activity, and has a strong cerebral vasodilatory action. Its hypotensive and peripheral vasodilatory activities were typical of many xanthine compounds

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The influence of catalyst in reaction 1028-33-7

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SDS of cas: 1028-33-7. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, is researched, Molecular C13H20N4O2, CAS is 1028-33-7, about Comparative intestinal absorption of a series of xanthines in aqueous or oil solutions. Author is Nook, T.; Doelker, E.; Buri, P..

The intestinal absorption of a group of xanthines from oil solutions was tested in rats by means of an in situ perfusion technique. Tributyrin  [60-01-5], tricaprylin  [538-23-8], and Et laurate  [106-33-2] were used as lipid vehicles able to increase the absorption of these drugs. For this series of xanthine derivatives, absorption was higher from oil solutions than from Sorensen buffer when the drug partition coefficient was <1. Although the affinity of the drugs for the vehicle was related to the absorption profiles, this could not explain all the absorption results. There was strong evidence that the nature of the oil plays concomitantly an important role. This was particularly the case for Et laurate, which highly increased the intestinal absorption of theophylline  [58-55-9]. Measurements of the appearance of this drug in the rat blood confirmed the favorable effect of this vehicle. Theophylline was further perfused as a suspension in Et laurate in order to test the effects of a higher drug-to-oil ratio. In this case, absorption from the oil suspension was of the same extent as an aqueous solution of identical concentration This seems to indicate that Et laurate may also affect the solubilization of the solid drug. When you point to this article, it is believed that you are also very interested in this compound(1028-33-7)SDS of cas: 1028-33-7 and due to space limitations, I can only present the most important information.

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The important role of 1028-33-7

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Application In Synthesis of 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, is researched, Molecular C13H20N4O2, CAS is 1028-33-7, about Analysis of purine derivatives. 14. Quantitative determination possibilities of 1-hexyltheobromine. Author is Raber, H..

1-Hexyltheobromine (I) is less soluble in H2O than the purines studied previously. Bromometric determination is possible using 100-200 mg in 70 ml MeOH, 50 ml 0.1N KBrO3, 1 g KBr in 5 m l H2O, 10 ml 6N H2SO4, and titration of the excess Br after 60 min. The factor is 1 ml 0.1N KBrO3 = 7.568 mg I. I can also be hydrolyzed and coupled to p-O2NC6H4N2+ followed by photometric determination as was done with Cordaline (CA 71: 128784s) except that 25% NEt4OH at 110-20° for 3 hr must be used in the hydrolysis and the aliquot of the hydrolyzed mixture must be neutralized to thymolphthalein by addition of NH4OAc before addition of urotropine, PrOH, and diazonium solution

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Archives for Chemistry Experiments of 1028-33-7

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Quality Control of 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, is researched, Molecular C13H20N4O2, CAS is 1028-33-7, about Intestinal absorption kinetics of various model drugs in relation to partition coefficients.

The kinetics of intestinal absorption of 9 drugs from aqueous solutions were studied in rats using an in situ perfusion technique. The results are discussed in the light of their partitioning behavior, blood flow and the unstirred water layer. Correlations between absorption rate constants and partition coefficients were either parabolic or hyperbolic and existing absorption models were applied to fit the data.

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Tetrahydrofuran – Wikipedia,
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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《[Influence of a Pentifylline-Nicotinic Acid Combination on Vigilance and Mental Performance (author’s transl)].》. Authors are Gessner, B; Klasser, M.The article about the compound:1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dionecas:1028-33-7,SMILESS:CN1C=NC(N(C(N2CCCCCC)=O)C)=C1C2=O).Recommanded Product: 1028-33-7. Through the article, more information about this compound (cas:1028-33-7) is conveyed.

The effect of a single dose of 4 sugar-coated tablets of Cosaldon (1-hexyl-3,7-dimethylxanthine (pentifylline) + nicotinic acid) was shown by quantitative pharmaco-EEG investigations and psychometric tests in 12 volunteers aged 58 to 75 years, who were in a good physical condition. The design was randomized, double-blind and cross-over designed against placebo. EEG and psychometric tests were made before medication and repeated each hour up to 6 h after medication. Each turn was split up into a resting-EEG (R-EEG) and a vigilance-EEG (V-EEG) lasting 3 min each; the psychometric tests were made immediately afterwards. An increase of the vigilance, shown by an increased EEG-power, was found after Cosaldon administration as compared to placebo. Furthermore, the delta and theta intensity decreased to a statistically significant degree, while the intensity within the alpha-1-scope increased. The strongest effect as compared to placebo could be observed 4 h after medication. The statistical significance was shown for the V-EEG-condition, the R-EEG showed only minor changes. The effects in the occipital region were stronger than in the more frontal parts. In accordance with the results of the EEG, the psychological tests showed remarkable improvements in performance which reached their maximum between 2 and 4 h after medication.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《SPECT monitoring of improved cerebral blood flow during long-term treatment of elderly patients with nootropic drugs.》. Authors are Dormehl, I C; Jordaan, B; Oliver, D W; Croft, S.The article about the compound:1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dionecas:1028-33-7,SMILESS:CN1C=NC(N(C(N2CCCCCC)=O)C)=C1C2=O).Reference of 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione. Through the article, more information about this compound (cas:1028-33-7) is conveyed.

PURPOSE: In normal aging persons, oxygen and glucose consumption progressively decreases with reduced cerebral blood flow (CBF), which could be responsible for age-related changes in cognitive functions. A data processing model with the use of Tc-99m SPECT of the human brain has been developed and found to be sensitive for monitoring the effects of drugs that increase CBF. In this study, the effect of two vasodilator drugs (the combination of pentifylline and nicotinic acid versus piracetam) was compared with the effect of placebo on CBF. MATERIALS AND METHODS: Thirty elderly volunteers had three different procedures using the Peelproc method to spatially standardize and compare CBF patterns by SPECT before and after drug intervention. The 30 patients were divided into five groups of six persons each who were randomly assigned in a 1:1 ratio to the treatment sequences consisting of three phases: the combination of pentifylline and nicotinic acid (C), piracetam (N), and placebo (P), or C-N-P; P-N-C; P-C-N; N-C-P; C-P-N; or N-P-C. Phases 1 to 3 each consisted of a baseline recording of parameters (day 0), treatment for 60 days (days 1 to 60), and recording of parameters after treatment (day 61). RESULTS: In elderly human volunteers (ages, 52 to 70 years), after 2 months of oral treatment with a combination of pentifylline and nicotinic acid (800 mg pentifylline, 200 mg nicotinic acid daily), SPECT results for the Peel-proc program indicated a statistically significant improvement in CBF of the total brain, with a more pronounced improvement in the cerebellum and frontal regions, where a definite shift from abnormal to normal blood flow was detected. Spontaneous communication from most of the volunteers suggested that they experienced an improvement in memory and general well-being from the combination treatment. After 2 months of oral treatment with piracetam (2.4 g daily) in elderly human volunteers, SPECT results indicated a regional improvement in CBF, particularly in the cerebellum. However, no beneficial effects with this drug were spontaneously reported. CONCLUSION: The in vivo method to quantitatively monitor the progress of long-term drug therapy on CBF described here could be useful to assess and even direct changes in therapy.

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Bhoir, Indravadan C.; Raman, Bhanu; Sundaresan, M.; Bhagwat, Ashok M. published the article 《Separation and estimation of seven vasodilators using packed column supercritical fluid chromatography》. Keywords: supercritical fluid chromatog vasodilator determination.They researched the compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione( cas:1028-33-7 ).Recommanded Product: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1028-33-7) here.

This paper reports a method for an isocratic separation and simultaneous estimation of 7 vasodilators: isosorbide mononitrate (ISMN), isosorbide dinitrate (ISDN), cyclandelate, nimodipine, amlodipine, pentifylline and pentoxifylline using packed column supercritical fluid chromatog. (SFC). An arbitrary choice of vasodilatory compounds with respect to their chem. structures was made to examine the viability of this technique for anal. of drugs and pharmaceuticals. Elution was performed on a RP-C18 column. SFC offers several degrees of freedom: temperature, pressure and modifier concentration to attain optimum resolution and sensitivity. The effects of these parameters on retention time were studied by using methanol modified carbon dioxide. The analytes were identified and measured by UV-detection. The chromatog. points of merit have been listed. Detection limits appear to be similar to those found in liquid chromatog. Modifier concentration does generally make major changes in retention and selectivity. A full scale validation for the seven vasodilators has been attempted and the statistical quality evaluated.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem