Category: 1028-33-7

Klotz, U.; Vapaatalo, H. published an article about the compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione( cas:1028-33-7,SMILESS:CN1C=NC(N(C(N2CCCCCC)=O)C)=C1C2=O ).SDS of cas: 1028-33-7. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1028-33-7) through the article.

Cyclic nucleotide phosphodiesterase (I) [9040-59-9] partly purified from rat diaphragm had a pH optimum of 7.0-8.0 and showed 2 apparent Km values for 3′,5′-cyclic AMP [60-92-4] hydrolysis in the low and high substrate concentration ranges, resp. Various pharmaceuticals inhibited I noncompetitively in the order eupaverin [1163-37-7] ≥ papaverine-HCl [61-25-6] > 1-hexyl-3,7-dimethylxanthine [1028-33-7] > Ro 7-2956 [26772-42-9] > theophylline [58-55-9] > d-tubocurarine chloride [57-94-3] > hydrochlorothiazide [58-93-5]. I was competitively inhibited by N6,2′-O-dibutyryl cyclic AMP [362-74-3] and cyclic GMP [7665-99-8] and noncompetitively by cyclic IMP [3545-76-4]. The mode of action of these drugs might be facilitation of the release of acetylcholine from motor nerve endings via the accumulation of cyclic AMP.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1028-33-7, is researched, Molecular C13H20N4O2, about Influence of pentifylline on brain metabolism of normal and anoxic rats, the main research direction is pentifylline brain energy metabolism anoxia.Product Details of 1028-33-7.

SK-7 (pentifylline)(I) [1028-33-7] (25 mg/kg, orally) stimulated the energy metabolism of the brain in normal and anoxic rats resulting in increased levels of ATP [56-65-5], total adenine nucleotide pool, glycogen [9005-79-2], and pyridine nucleotides (NAD [53-84-9] and NADH2 [58-68-4]).

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Reference:
Tetrahydrofuran – Wikipedia,
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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione( cas:1028-33-7 ) is researched.Electric Literature of C13H20N4O2.Hassib, Sonia T. published the article 《Simultaneous determination of pentifylline and nicotinic acid by derivative spectrophotometry》 about this compound( cas:1028-33-7 ) in Egyptian Journal of Pharmaceutical Sciences. Keywords: pentifylline nicotinate determination derivative spectrophotometry. Let’s learn more about this compound (cas:1028-33-7).

First-derivative spectrophotometry with a zero-crossing technique of measurement was used for the quantitation of a mixture of pentifylline and nicotinic acid (4:1). Pentifylline was also evaluated in the presence of nicotinic acid by first and second-derivative modes applying peak-height measurement. Cosaldon Retard tablets were estimated for pentifylline and nicotinic acid in success using first-derivative mode.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

SDS of cas: 1028-33-7. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, is researched, Molecular C13H20N4O2, CAS is 1028-33-7, about Prevention of side effects in electroshock therapy. Author is Jovanovic, U. J..

Female patients with endogenous psychoses, mostly with depressive symptoms, were treated with electroshock; some of them received 3 tablets of Cosaldon, containing 200 mg. 1-hexyl-3,7-dimethylxanthine and 50 mg. nicotinic acid/tablet, daily during therapy. For the group treated with Cosaldon the period of current flow necessary to induce convulsions was 2.57 sec. compared with 3.52 sec. in the untreated group. The average period of apnea and cyanosis in the treated group was 3.48 sec. compared with 25.2 sec. in the untreated. The frequency, amplitude, and α-wave rhythms of the electroencephalograms of Cosaldon-treated patients remained normal, and no convulsion-like or genuine convulsion elements were registered, while the electroencephalograms of untreated patients displayed moderate to serious changes. The protective mechanisms of Cosaldon for the brain during electroshock therapy are probably via inhibition of cerebral vascular spasms and anoxia. 66 references.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

COA of Formula: C13H20N4O2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, is researched, Molecular C13H20N4O2, CAS is 1028-33-7, about Absorption studies with purines. Part 1. In vitro determination with the Sartorius absorption model according to Stricker. Author is Heppt-Becker, I.; Schunack, W..

The diffusion constants of 8 alkylpurines across Sartorius membrane filters (as a model for the digestive tract), determined at various pH values, depended on the lipid solubility and polarity of the drugs, being greatest for the lipophilic 1-hexyltheobromine [1028-33-7] and lowest for the hydrophilic diprophylline (I) [479-18-5].

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Recommanded Product: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, is researched, Molecular C13H20N4O2, CAS is 1028-33-7, about Non-human primate SPECT model for determining cerebral perfusion effects of cerebrovasoactive drugs acting via multiple modes of pharmacological action. Author is Oliver, Douglas W.; Dormehl, Irene C.; Louw, Werner K. A..

Increasing clin. and exptl. evidence implicate cerebral hypoperfusion during increased aging and points to chronic cerebrovascular ischemia as a vital component of the neuropathol. progression of dementia. In vivo cerebral perfusion animal models can greatly contribute to the evaluation of drugs and to the screening of drug interactions. This study describes a baboon Papio ursinus model under anesthesia, for in vivo cerebral blood flow (CBF) determinations, using Single Photon Emission Computed Tomog. (SPECT) following the split-dose method with 99mTc-hexamethylpropylene amine oxime (99mTc-HMPAO). Perfusion studies with acetazolamide as intervention clearly showed that the non-human primate model under aneasthesia is sufficiently sensitive to serve in the evaluation of other cerebrovasoactive drugs for induced perfusion changes with significant increases of the R-value (+40%) for comparative measurement when compared to the control value (2.53±0.15 vs. 1.79±0.13). These findings stimulated investigations of several drugs, i.e. pentifylline (phosphodiesterase inhibitor); nimodipine (calcium channel blocker); sumatriptan (serotonin receptor agonist) and nicotinic acid (vasodilator) for CBF effects. Increases in the cerebral perfusion in some cases more than +30% for nimodipine (2.51±0.14 vs. 1.79±0.13), acetazolamide and +29% for the combination of pentifylline and nicotinic acid (2.31±0.19 vs. 1.79±0.13) were observed Drug interaction studies revealed an attenuation of increased CBF due to nimodipine, with sumatriptan (-25%) and acetazolamide (+22%) in combination with nimodipine. Drug interactions with clin. implications may result during simultaneous use of cerebrovasoactive drugs in managing patients with cerebrovascular disorders. This study further showed that the CBF non-human primate model under anesthesia is useful for the investigation of vasoactive drugs acting via various pharmacol. modes of action.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Formula: C13H20N4O2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, is researched, Molecular C13H20N4O2, CAS is 1028-33-7, about Effect of pentifylline and theophylline on reaction kinetics on rat brain ATPase stimulatable by catecholamines. Author is Porsche, E.; Stefanovich, V..

The effects of pentifylline (I) [1028-33-7] and theophylline (II) [58-55-9] on rat brain Na+-, K+-, Mg2+- ATPase [9000-83-3] activities were investigated in in vitro experiments I inhibited catecholamine-sensitive ATPase in a dose-dependent manner. II was without effect. I also inhibited the Mg2+-dependent portion of Na+-, K+-, Mg2+-ATPase. I also altered the kinetic parameters of Na+-, K+-, Mg2+-ATPase of brain synaptosomes. It was shown by a Lineweaver-Burk plot that increased the Michaelis constant (Km) from 1.0 × 10-4 to 6.7 × 10-4 mol/L. Km By norepinephrine-stimulated ATPase decreased from 3.7 to 2.9 × 10-4 mol/L. At high concentrations of K+ in incubation medium, the ATPase of synaptosomes was significantly more sensitive to I than at low concentrations of K+. The inhibition of ATPase by I was not influenced by the change in Na+/K+ ratio in the incubation medium. II used as a standard xanthine, was virtually without effect on the reaction kinetics of Na+-, K+-ATPase.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Electric Literature of C13H20N4O2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, is researched, Molecular C13H20N4O2, CAS is 1028-33-7, about Acute cellular rejection in small-bowel transplantation impairs NCR+ innate lymphoid cell subpopulation 3/interleukin 22 axis. Author is Pucci Molineris, Melisa; Gonzalez Polo, Virginia; Rumbo, Carolina; Fuxman, Claudia; Lowestein, Carlos; Nachman, Fabio; Rumbo, Martin; Gondolesi, Gabriel; Meier, Dominik.

Acute cellular rejection (ACR) remains as one of the main causes of graft loss and death in intestinal transplant (ITx) patients. ACR promotes intestinal injury, disruption of the mucosal barrier, bacterial translocation, and organ dysfunction. As epithelial regeneration is critical in reversing these consequences, the functional axis between the innate lymphoid cell subpopulation 3 (ILC3) and interleukin 22 plays an essential role in that process. Natural-cytotoxic-receptor-pos. (NCR+) ILC3 cells have been demonstrated to induce intestinal-stem-cell proliferation along with an IL-22-dependent expansion of that population in several intestinal pathologies, though thus far not after ITx. Therefore, we intended to determine the impact of chronic immunosuppression and ACR on ILC3 cells and interleukin-22 (IL-22) production in the lamina propria after that intervention. We compared biopsies from healthy volunteers with biopsies from ITx recipients without or with mild-to-moderate ACR, using flow cytometry and the quant.-PCR. NCR+ ILC3 cells were found to be unaffected by immunosuppression at different time points posttransplant when patients did not experience ACR, but were diminished upon the occurrence of ACR independently of the post-ITx time. Moreover, IL-22-expression levels were notably reduced in ACR. The NCR+-ILC3/IL-22 axis is impaired during ACR contributing to a delay in or lack of a complete and efficient epithelial regeneration.

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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Absorption, distribution, excretion, and degradation of 1-hexyl-3,7-dimethylxanthine, published in 1966, which mentions a compound: 1028-33-7, mainly applied to DIMETHYLXANTHINES METAB; METAB DIMETHYLXANTHINES; XANTHINES METAB; URINE METABOLITES DIMETHYLXANTHINES, Formula: C13H20N4O2.

1-Hexyl-3,7-dimethylxanthine, administered orally or rectally to rabbits, was rapidly absorbed and persisted in the blood, liver, brain, myocardium, and skeletal muscles for several hrs. Less than 1% of the administered dose was excreted without undergoing chem. transformation. Following prolonged oral administration of 1-hexyl-3,7-dimethylxanthine (500 mg./day), 50% of the administered dose was excreted in the urine in 24 hrs. as metabolities formed by oxidation of the hexyl radical side chain. A small fraction of 1-hexyl-3,7-dimethylaxanthine metabolites was excreted in the feces, after enterohepatic circulation. Urinary metabolites identified included 1-(5′-hydroxyhexyl)-3,7-dimethyl-xanthine, 1-(5′-ketohexyl)-3,7-dimethylxanthine, 1-(4′,5′-dihydroxyhexyl)-3,7-dimethylxanthine, and 1-(3′-carboxypropyl)-3,7-dimethylxanthine. 60 references.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Mechanism of the antagonistic action of xanthine derivatives against adenosine and coronary vasodilators, published in 1972, which mentions a compound: 1028-33-7, Name is 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, Molecular C13H20N4O2, SDS of cas: 1028-33-7.

The coronary dilating activity of adenosine (I) [58-61-7], dipyridamole (II) [58-32-2], and lidoflazine (III) [3416-26-0] in anesthetized dogs was inhibited by 1-substituted xanthines, e.g. caffeine (IV) [58-08-2] or theophylline (V) [58-55-9], provided the substituent was small and no substituent was present at the 7 position. The enhancement of the coronary dilating activity of I by II and III was not inhibited by IV or V. The suppression of I permeation through erythrocyte membranes caused by II or III was not reversed by V. The coronary vasodilation induced by carbocromene [804-10-4], which did not suppress the I permeation through erythrocyte membranes, was not influenced by IV or V, indicating a different mode of action.

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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem