21461-84-7, Name is (S)-( )-5-Oxo-2-tetrahydrofurancarboxylic Acid, belongs to Tetrahydrofurans compound, is a common compound. 21461-84-7In an article, authors is Anderl, Felix, once mentioned the new application about 21461-84-7.
Total Synthesis of Belizentrin Methyl Ester: Report on a Likely Conquest
The assigned structure of the dinoflagellate-derived toxin belizentrin was prepared by total synthesis in form of the corresponding methyl ester for stability reasons. The successful route features an unusual solution for the preparation of a recalcitrant ylide on a C-glycosidic segment; moreover, it involves an asymmetric hetero-Diels?Alder reaction en route to the tertiary hemiacetal substructure, a Negishi cross-coupling of two elaborate building blocks, and a macrocyclization based on an intramolecular aminolysis of a spirolactone. A modified Kocienski olefination ultimately allowed the polyol side chain to be attached to the macrocycle although this transformation faced the exceptional base sensitivity of this polyunsaturated target compound.
Do you like my blog? If you like, you can also browse other articles about this kind. 21461-84-7Thanks for taking the time to read the blog about 21461-84-7
Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem