Discovery of 52079-23-9

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 52079-23-9 is helpful to your research. 52079-23-9

52079-23-9, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 52079-23-9, name is (S)-(-)-alpha-Hydroxy-gamma-butyrolactone. In an article£¬Which mentioned a new discovery about 52079-23-9

Homochiral 2,4-Disubstituted 1,3-Dioxanes from (S)-(-)-Malic Acid: Stereoselective Synthesis and Investigation of the NMDA Receptor Affinity of All Four Stereoisomers

Starting from a single enantiomerically pure compound, (S)-(-)-malic acid, all four stereoisomeric 4-dimethylaminomethyl-2-phenyl-1,3-dioxanes (S,S)-15, (R,R)-15 (S,R)-16, and (R,S)-16 are prepared: Transacetalisation of benzaldehyde dimethyl acetal (6b) with (S)-(-)-methyl 2,4-dihydroxybutyrate (7a), which is obtained by chemoselective BH3 reduction of (S)-(-)-malic acid monoester 8b, yields the diastereomeric 1,3-dioxane derivatives (S,S)-10 and (R,S)-11 in a 85:15 ratio.LDA deprotonation of (S,S)-10 followed by protonation leads to C-4 epimerisation <(S,S)-10:(S,R)-11 = 30;70>.The thermodynamically controlled 88:12 equilibrium of (R,R)-10 and (S,R)-11 is reached by treatment of (S,R)-11 with acid.Aminolysis with dimethylamine and subsequent LiAlH4 reduction transform the four stereoisomeric esters (S,S)-10, (R,R)-10, (S,R)-11 and (R,S)-11 to give the amines (S,S)-15, (R,R)-15, (S,R)-16 and (R,S)-16, respectively.In the 3H-(+)-MK 801 displacement experiment (S,S)-15, (R,R)-15, (S,R)-16 and (R,S)-16 show a very little affinity to the phencyclidine binding site in the cation channel associated with the NMDA receptor. – Key Words: Butyric acid derivatives, (S)-(-)-24-dihydroxy-/ 1,3-Dioxanes/ NMDA antagonists, noncompetitive

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 52079-23-9 is helpful to your research. 52079-23-9

Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem