S-Adenosyl methionine cofactor modifications enhance the biocatalytic repertoire of small molecule C-alkylation was written by McKean, Iain J. W.;Sadler, Joanna C.;Cuetos, Anibal;Frese, Amina;Humphreys, Luke D.;Grogan, Gideon;Hoskisson, Paul A.;Burley, Glenn A.. And the article was included in Angewandte Chemie, International Edition in 2019.Reference of 4097-22-7 This article mentions the following:
A tandem enzymic strategy to enhance the scope of C-alkylation of small mols. via the in situ formation of S-adenosyl methionine (SAM) cofactor analogs is described. A solvent-exposed channel present in the SAM-forming enzyme SalL tolerates 5′-chloro-5′-deoxyadenosine (ClDA) analogs modified at the 2-position of the adenine nucleobase. Coupling SalL-catalyzed cofactor production with C-(m)ethyl transfer to coumarin substrates catalyzed by the methyltransferase (MTase) NovO forms C-(m)ethylated coumarins in superior yield and greater substrate scope relative to that obtained using cofactors lacking nucleobase modifications. Establishing the mol. determinants that influence C-alkylation provides the basis to develop a late-stage enzymic platform for the preparation of high value small mols. In the experiment, the researchers used many compounds, for example, ((2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol (cas: 4097-22-7Reference of 4097-22-7).
((2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol (cas: 4097-22-7) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.Reference of 4097-22-7
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem