Alteration of cross-linking selectivity with the 2′-OMe analogue of 2-amino-6-vinylpurine and evaluation of antisense effects was written by Imoto, Shuhei;Hori, Tsuneaki;Hagihara, Shinya;Taniguchi, Yosuke;Sasaki, Shigeki;Nagatsugi, Fumi. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Application of 2140-71-8 This article mentions the following:
We previously reported that oligodeoxynucleotides containing 2-amino-6-vinylpurine (2-AVP) exhibit efficient selective crosslinking to cytosine. In this study, the 2′-OMe nucleoside analog (2) of 2-AVP was designed in order to increase its affinity to RNA and enhance metabolic stability. It has been demonstrated that 2′-OMe oligonucleotides bearing 2 achieve highly selective crosslinking to the thymine base in DNA and show higher antisense effect on luciferase production in cell lysate. In the experiment, the researchers used many compounds, for example, 2-Amino-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-1H-purin-6(9H)-one (cas: 2140-71-8Application of 2140-71-8).
2-Amino-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-1H-purin-6(9H)-one (cas: 2140-71-8) belongs to tetrahydrofuran derivatives. Tetrahydrofurans and furans are important oxygen-containing heterocycles that often exhibit interesting properties for biological applications or applications in the cosmetic industry. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.Application of 2140-71-8
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem