The synthesis of partially-protected 2′-deoxyribonucleotide dimers by the selective phosphorylation of stannylated nucleosides was written by Kawana, Masajiro;Kuzuhara, Hiroyoshi. And the article was included in Bulletin of the Chemical Society of Japan in 1984.SDS of cas: 4836-13-9 This article mentions the following:
In the new method for the synthesis of the title compounds, the activation of the hydroxyl moieties of 5′-O-dimethoxytrityl and 3′,5′-unprotected 2′-deoxyribonucleosides, which were appropriately protected on their base residues, was done with (Bu3Sn)2O in sep. flasks. The resulting stannylated nucleosides were coupled with 2-chlorophenyl phosphorodichloridate to form the dimers with 3’→4′ internucleotide linkages in yields of more than 71%, along with the corresponding 3′ → 3′ isomers in yields of less than 10%. The method of Cashion et al. was also evaluated, in which up-to-date protecting groups were employed. In the experiment, the researchers used many compounds, for example, N-(1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide (cas: 4836-13-9SDS of cas: 4836-13-9).
N-(1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide (cas: 4836-13-9) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.SDS of cas: 4836-13-9
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem