A correlation for 1,9-decadiene/water partition coefficients was written by Nitsche, Johannes M.;Kasting, Gerald B.. And the article was included in Journal of Pharmaceutical Sciences in 2013.Quality Control of ((2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol This article mentions the following:
An important series of papers by Xiang, Anderson, and coworkers has established the strong correlation between phospholipid bilayer membrane permeability and the 1,9-decadiene/water partition coefficient over a wide range of compounds, elevating the importance of Kdecadiene/w as a predictor of mol. bioavailability. On the basis of a 58-point dataset developed by these authors, this research note develops an optimal correlation predicting log10Kdecadiene/w in terms of the octanol/water partition coefficient and four of the Abraham solvation parameters, namely A (hydrogen bond acidity), S (polarity/polarizability), E (excess molar refraction), and V (McGowan characteristic volume). The fitted dataset is described to within a root-mean-square error of 0.42, and the probable error in making a prediction for a compound not present therein is 0.49. It is shown that this correlation error for Kdecadiene/w is the dominant source of uncertainty in applying a comprehensive new model of phospholipid bilayer membrane permeability developed in a companion paper (Nitsche and Kasting, submitted for publication), which superposes the effects of mol. size and lipid d. upon the decadiene lipophilicity scale. Thus, more exptl. studies to augment the limited existing database on Kdecadiene/w are called for. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci. In the experiment, the researchers used many compounds, for example, ((2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol (cas: 4097-22-7Quality Control of ((2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol).
((2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol (cas: 4097-22-7) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. Tetrahydrofuran (THF) is primarily used as a precursor to polymers including for surface coating, adhesives, and printing inks.Quality Control of ((2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methanol
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem