Laser desorption/Fourier-transform mass spectrometry for the study of nucleosides, oligosaccharides, and glycosides was written by McCrery, David A.;Gross, Michael L.. And the article was included in Analytica Chimica Acta in 1985.Quality Control of 2-Amino-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-1H-purin-6(9H)-one This article mentions the following:
Laser desorption/Fourier-transform mass spectrometry (l.d./F.t.m.s.) was used to investigate the feasibility of desorbing nucleosides, oligosaccharides, and glycosides into the gas phase. Nucleosides were desorbed as (M – H)– ions or as (M + H)+ or, more readily, as alkali metal ion cationized species. Monosaccharides also could be desorbed as (M – H)–, but not di- or trisaccharides. At higher laser irradiance, very abundant cationized oligosaccharides were observed This was particularly true when the Nd:YAG laser was operated in a non-Q-switched mode to give a longer lasting laser pulse. Ions of nonreducing sugars cleaved at the glycosidic bond, but those of reducing sugars underwent ring cleavage reactions. Various glycosides including quercitrin, rutin, xanthorhamnin, digoxin, digitoxin, and erythromycin were also successfully desorbed as cationized species by using l.d./F.t.m.s. Digoxin and digitoxin (M + Na)+ ions fragment different than the (M + H)+ ions, presumably because the Na+ is primarily affiliated with the sugar moiety, whereas H+ is bound on the steroid portion of the mol. In the experiment, the researchers used many compounds, for example, 2-Amino-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-1H-purin-6(9H)-one (cas: 2140-71-8Quality Control of 2-Amino-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-1H-purin-6(9H)-one).
2-Amino-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-1H-purin-6(9H)-one (cas: 2140-71-8) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. Tetrahydrofuran can also be produced, or synthesised, via catalytic hydrogenation of furan. This process involves converting certain sugars into THF by digesting to furfural. An alternative to this method is the catalytic hydrogenation of furan with a nickel catalyst.Quality Control of 2-Amino-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-1H-purin-6(9H)-one
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem