Improved methods for protection of hydroxyls of carbohydrates using acetyl and benzyl radicals was written by Jiang, Yu-hua;Fang, Zhi-jie;Jiao, Yan;Li, Hong-wei. And the article was included in Huaxue Shiji in 2008.Category: tetrahydrofurans This article mentions the following:
The process for preparing acetyl protected monosaccharide and disaccharide were optimized using HClO4/SiO2 as the acetylating catalyst. Instead of using silica column chromatog., recrystallization and extraction were applied to simplify the process for isolation of products. It was found that this process could use less Ac2O with advantages featuring quick reaction rate, high efficiency and environmentally friendly property. Furthermore, several benzyl-protected disaccharides were prepared from peracetyldisaccharides and the yield of octa-benzyl sucrose was improved notably. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5R,6R)-2-(Acetoxymethyl)-6-(((2S,3S,4R,5R)-3,4-diacetoxy-2,5-bis(acetoxymethyl)tetrahydrofuran-2-yl)oxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate (cas: 126-14-7Category: tetrahydrofurans).
(2R,3R,4S,5R,6R)-2-(Acetoxymethyl)-6-(((2S,3S,4R,5R)-3,4-diacetoxy-2,5-bis(acetoxymethyl)tetrahydrofuran-2-yl)oxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate (cas: 126-14-7) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. Tetrahydrofuran can also be produced, or synthesised, via catalytic hydrogenation of furan. This process involves converting certain sugars into THF by digesting to furfural. An alternative to this method is the catalytic hydrogenation of furan with a nickel catalyst.Category: tetrahydrofurans
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem