Stimulation of the extracellular Ca2+-sensing receptor by denatonium was written by Rogachevskaja, Olga A.;Churbanov, Gleb D.;Bystrova, Marina F.;Romanov, Roman A.;Kolesnikov, Stanislav S.. And the article was included in Biochemical and Biophysical Research Communications in 2011.Category: tetrahydrofurans This article mentions the following:
The extracellular Ca2+-sensing receptor (CASR) is a promiscuous G-protein-coupled receptor closely related to the taste receptors T1R1-T1R3. Here we analyzed the possibility that apart from being stimulated by external Ca2+ and amino acids, the substances effective as tastants, CASR might serve as a receptor for other sapid compounds CASR was heterologously expressed in HEK-293 cells, and their responsivity to a variety of bitter and sweet substances was examined Among them, solely denatonium was found to stimulate Ca2+ signaling in CASR-pos. HEK-293 cells. Apparently, these Ca2+ responses were specific, as those were inhibited by the CASR antagonist NSP-4123. Altogether, our findings indicate that denatonium stimulates CASR by shifting a dose-response curve for the principal CASR agonist Ca2+ to lower concentrations In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5R,6R)-2-(Acetoxymethyl)-6-(((2S,3S,4R,5R)-3,4-diacetoxy-2,5-bis(acetoxymethyl)tetrahydrofuran-2-yl)oxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate (cas: 126-14-7Category: tetrahydrofurans).
(2R,3R,4S,5R,6R)-2-(Acetoxymethyl)-6-(((2S,3S,4R,5R)-3,4-diacetoxy-2,5-bis(acetoxymethyl)tetrahydrofuran-2-yl)oxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate (cas: 126-14-7) belongs to tetrahydrofuran derivatives. Tetrahydrofuran and dihydrofuran form the basic structural unit of many naturally occurring scaffolds like gambieric acid A and ciguatoxin, goniocin, and some biologically active molecules. Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.Category: tetrahydrofurans
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem