Study on the Synthesis and PKA-I Binding Activities of 5-Alkynyl Tubercidin Analogues was written by Zhang, Liangren;Zhang, Yunlong;Li, Xianghui;Zhang, Lihe. And the article was included in Bioorganic & Medicinal Chemistry in 2002.Application of 24386-93-4 The following contents are mentioned in the article:
5-Alkynyl tubercidin analogs were synthesized and their biol. activities were evaluated. It was found that protein kinase A could be activated by 5-alkynyl tubercidin (I) and cAMP-binding ability to PKA-I was selectively inhibited by it. Mol. modeling showed that the interaction of I and PKA-I was associated with the existence of hydrophobic alkynyl group. During the synthesis of tubercidin analogs, a pair of 2′-carbonyl participating abnormal coupling products was obtained, the structure was identified by X-ray crystalline diffraction. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (cas: 24386-93-4Application of 24386-93-4).
(2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (cas: 24386-93-4) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. Tetrahydrofuran can also be produced, or synthesised, via catalytic hydrogenation of furan. This process involves converting certain sugars into THF by digesting to furfural. An alternative to this method is the catalytic hydrogenation of furan with a nickel catalyst.Application of 24386-93-4
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem