Wang, Xiaojing et al. published their research in Nucleosides, Nucleotides & Nucleic Acids in 2004 | CAS: 24386-93-4

(2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (cas: 24386-93-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF) is a Lewis base that bonds to a variety of Lewis acids such as I2, phenols, triethylaluminum and bis(hexafluoroacetylacetonato)copper(II). Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Category: tetrahydrofurans

Synthesis and Biological Activity of 5-Fluorotubercidin was written by Wang, Xiaojing;Seth, Punit P.;Ranken, Ray;Swayze, Eric E.;Migawa, Michael T.. And the article was included in Nucleosides, Nucleotides & Nucleic Acids in 2004.Category: tetrahydrofurans The following contents are mentioned in the article:

The electrophilic fluorination of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine was studied culminating a 59% conversion to 4-chloro-5-fluoro-7H-pyrrolo[2,3-d]-pyrimidine (I) using Selectfluor. This transformation proceeded via the 4-chloro-5,6-dihydro-5-fluoro-6-hydroxy-7H-pyrrolo[2,3-d]pyrimidine (II) in a 9:1 trans:cis ratio. Trans-II was studied by 1H NMR and 19F NMR, and the 5-H tautomer was observed as another intermediate. A modified Vorbruggen procedure of I and 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose gave tri-O-benzoyl-5-fluorotubercidin III (R = COPh) in a 65% yield. Treatment III (R = COPh) with ammonia in dioxane gave 5-fluorotubercidin III (R = H). No antibacterial activity was observed An MTT assay (Promega) against Huh-7 liver cells, normal mouse spleen cells stimulated with Con A (a T-cell mitogen), and normal mouse spleen stimulated with LPS (a B-cell mitogen) showed no significant toxicity. Increased activity of 5-fluorotubercidin over tubercidin was observed against L-1210 cells and toxicity in fibroblast cells was reduced. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (cas: 24386-93-4Category: tetrahydrofurans).

(2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (cas: 24386-93-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF) is a Lewis base that bonds to a variety of Lewis acids such as I2, phenols, triethylaluminum and bis(hexafluoroacetylacetonato)copper(II). Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Category: tetrahydrofurans

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem