Analyzing the synthesis route of 917882-94-1

917882-94-1 N-Methyltetrahydrofuran-3-amine hydrochloride 53404832, aTetrahydrofurans compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.917882-94-1,N-Methyltetrahydrofuran-3-amine hydrochloride,as a common compound, the synthetic route is as follows.,917882-94-1

TEA (1.5 mL, 10.963 mmol) was added to a room temperature stirred solution of N-methyltetrahydrofuran-3-amine hydrochloride (0.754 g, 5.4815 mmol) in DCM (5 mL), followed by the addition of a solution of Intermediate 3 (1.08 g, 3.6543 mmol) in DCM (5 mL). The reaction mixture was stirred at rt for 20 h and, after completion, was concentrated under reduced pressure. The product obtained was purified by silica gel chromatography using a gradient of 50-70% ethyl acetate in hexane as eluent. The fractions were combined and concentrated to dryness to afford the title compound (0.24 g, 18%) as a semisolid. MH+ 360.14;

917882-94-1 N-Methyltetrahydrofuran-3-amine hydrochloride 53404832, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; NEOMED INSTITUTE; POURASHRAF, Mehrnaz; BEAULIEU, Marc-Andre; CLARIDGE, Stephen; BAYRAKDARIAN, Malken; JOHNSTONE, Shawn; ALBERT, Jeffrey S.; GRIFFIN, Andrew; (135 pag.)WO2017/66876; (2017); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem