Brzezinska, Jolanta published the artcileNon-nucleosidic analogues of polyaminonucleosides and their influence on thermodynamic properties of derived oligonucleotides, Quality Control of 19444-84-9, the publication is Molecules (2015), 20(7), 12652-12669, database is CAplus and MEDLINE.
The rationale for the synthesis of cationic modified nucleosides is higher expected nuclease resistance and potentially better cellular uptake due to an overall reduced neg. charge based on internal charge compensation. Due to the ideal distance between cationic groups, polyamines are perfect counterions for oligodeoxyribonucleotides. We have synthesized non-nucleosidic analogs built from units that carry different diol structures instead of sugar residues and functionalized with polyamines. The non-nucleosidic analogs were attached as internal or 5′-terminal modifications in oligodeoxyribonucleotide strands. The thermodn. studies of these polyaminooligonucleotide analogs revealed stabilizing or destabilizing effects that depend on the linker or polyamine used.
Molecules published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Quality Control of 19444-84-9.
Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem