Anti-parasite activity of nucleoside analogs in Leishmania tropica promastigotes was written by Wataya, Y.; Hiraoka, O.; Sonobe, Y.; Yoshioka, A.; Matsuda, A.; Miyasaka, T.; Saneyoshi, M.; Ueda, T.. And the article was included in Nucleic Acids Symposium Series in 1984.COA of Formula: C10H12N4O4 The following contents are mentioned in the article:
Many nucleoside analogs were screened for antiprotozoal activity on L. tropica in an in vitro culture system. 3′-Deoxyinosine and several tubercidin derivatives were potent inhibitors for growth of the promastigote form of L. tropica. This compound was markedly less toxic towards mouse mammary tumor FM3A cells. 3′-Deoxyinosine is metabolized by Leishmania promastigote to give 3′-deoxyinosine-5′-monophosphate and 3′-deoxyadenosine(cordycepin)-5′-mono, di-, and triphosphates. This means that Leishmania can aminate the 6-position of 3′-deoxyinosine-5′-monophosphate, thereby converting it into a highly toxic compound This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0COA of Formula: C10H12N4O4 ).
9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is water-miscible and has a low viscosity making it a highly versatile solvent used in a variety of industries. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.COA of Formula: C10H12N4O4
13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0