Synthesis of 2′- and 3′-deoxyinosines was written by Yamazaki, Akihiro; Akiyama, Masao; Kumashiro, Izumi; Ikehara, Morio. And the article was included in Chemical & Pharmaceutical Bulletin in 1973.Formula: C10H12N4O4 The following contents are mentioned in the article:
Isopropylidenation of 8-mercaptoinosine with Me2C(OMe)2 in HClO4, followed by acetylation with Ac2O in pyridine, and then deisopropylidenation gave 5′-O-acetyl-8-mercaptoinosine (I). Tosylation of I, followed by treatment with NH3 in MeOH at 0° gave 18% 8,2′-anhydro-8-mercapto-9-β-D-arabino-(II) and 5.1% 8,3′-anhydro-8-mercapto-9-β-D-xylofuranosylhypoxanthine (III). Refluxing II and III with Raney Ni in aqueous solution gave 2′-deoxy- and 3′-deoxyinosine, resp. Treatment of II with POCl3 in (MeO)3PO, followed by hydrolysis gave 8.5% of the 5′-phosphate ester of II. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Formula: C10H12N4O4 ).
9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. Commercial tetrahydrofuran contains substantial water that must be removed for sensitive operations, e.g. those involving organometallic compounds. Although tetrahydrofuran is traditionally dried by distillation from an aggressive desiccant, molecular sieves are superior.Formula: C10H12N4O4
13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0