Synthesis and evaluation of the substrate activity of C-6 substituted purine ribosides with E. coli purine nucleoside phosphorylase: Palladium mediated cross-coupling of organo-zinc halides with 6-chloropurine nucleosides was written by Hassan, Abdalla E. A.; Abou-Elkhair, Reham A. I.; Riordan, James M.; Allan, Paula W.; Parker, William B.; Khare, Rashmi; Waud, William R.; Montgomery, John A.; Secrist, John A. III. And the article was included in European Journal of Medicinal Chemistry in 2012.Product Details of 550-33-4 The following contents are mentioned in the article:
A series of C-6 alkyl, cycloalkyl, and aryl-9-(β-D-ribofuranosyl)purines were synthesized and their substrate activities with Escherichia coli purine nucleoside phosphorylase (E. coli PNP) were evaluated. (Ph3P)4Pd-mediated cross-coupling reactions of 6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-purine (I) with primary alkyl (Me, Et, n-Pr, n-Bu, isoBu) zinc halides followed by treatment with NH3/MeOH gave the corresponding 6-alkyl-9-(β-D-ribofuranosyl)purine derivatives, e.g. II, 7-11, resp., in good yields. Reactions of I with cycloalkyl(Pr, Bu, pentyl)zinc halides and aryl (Ph, 2-thienyl)zinc halides gave under similar conditions the corresponding 6-cyclopropyl, cyclobutyl, cyclopentyl, Ph, and thienyl-9-(β-D-ribofuranosyl)purine derivatives in high yields. E. coli PNP showed a high tolerance to the steric and hydrophobic environment at the 6-position of the synthesized purine ribonucleosides. Evaluation of II against human tumor xenografts in mice did not demonstrate any selective antitumor activity. In addition, 6-methyl-9-(β-D-arabinofuranosyl)purine was prepared and evaluated for its antitumor activity. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Product Details of 550-33-4).
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. Tetrahydrofurans and furans are important oxygen-containing heterocycles that often exhibit interesting properties for biological applications or applications in the cosmetic industry. Tetrahydrofuran (THF) is primarily used as a precursor to polymers including for surface coating, adhesives, and printing inks.Product Details of 550-33-4
550-33-4;(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol;The future of 550-33-4;New trend of C10H12N4O4 ;function of 550-33-4