Nucleosides and nucleotides. 143. Synthesis of 5-amino-4-imidazolecarboxamide (AICA) deoxyribosides from deoxyinosines and their conversion into 3-deazapurine derivatives was written by Minakawa, Noriaki; Sasabuchi, Yoshimasa; Kiyosue, Arihiro; Kojima, Naoshi; Matsuda, Akira. And the article was included in Chemical & Pharmaceutical Bulletin on February 29,1996.Reference of 13146-72-0 The following contents are mentioned in the article:
An efficient and large scale chem. synthesis of 5-aminoimidazole-4-carboxamide (AICA) deoxyribonucleosides I (R = OH, R1 = H; R = H, R1 = OH) is described. Treatment of 3′,5′-di-O-acetyl-N1-triphenylmethyl-2′-deoxyinosine with 5 N NaOH in EtOH, followed by anhydrous trifluoroacetic acid gave I (R = OH, R1 = H) in 59% yield from 2′-deoxyinosine. AICA 3′-deoxyriboside I (R = H, R1 = OH) was also obtained in a similar manner in 73% yield from 3′-deoxyinosine. Conversion of I into 3-deazapurines, e.g. II, is also described. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Reference of 13146-72-0).
9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. THF can also be synthesized by catalytic hydrogenation of furan. This allows certain sugars to be converted to THF via acid-catalyzed digestion to furfural and decarbonylation to furan, although this method is not widely practiced. THF is thus derivable from renewable resources.Reference of 13146-72-0
13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0