An inhibitor of mannosylation of retinyl-phosphate was written by Datema, Roelf; Schwarz, Ralph T.. And the article was included in Bioscience Reports on March 31,1984.COA of Formula: C15H23FN2O16P2 The following contents are mentioned in the article:
The guanosine disphosphate and uridine diphosphate esters of the antiviral sugar analog 2-deoxy-2-fluoro-D-glucose (GDP-FGlc [67341-45-1] and UDP-FGlc [67341-43-9]) were synthesized and tested as inhibitors of formation of lipid-linked sugars in cell-free extracts Formation of dolichol phosphate mannose [55598-56-6] and of dolichol diphosphate di-N-acetylchitobiose were not inhibited by either sugar nucleotide. Formation of dolichol phosphate glucose [55607-88-0] was inhibited by UDP-FGlc, but not by GDP-FGlc. Although GDP-FGlc did not inhibit formation of dolichol phosphate mannose, it did inhibit formation of retinyl phosphate mannose [55722-25-3] from retinyl phosphate [53859-19-1] and GDP-mannose. This inhibition was not reversed by exogenous retinyl phosphate, nor was FGlc from GDP-Glc incorporated into retinyl phosphate-linked derivatives As FGlc inhibits formation of dolichol phosphate mannose in intact cells, but does not decrease pool sizes of GDP-mannose and dolichol-phosphate (Datema, R., et al., 1980), that inhibition of formation of retinyl-phosphate mannose by one of the metabolites of FGlc, namely GDP-FGlc, may lead to decreased synthesis of dolichol phosphate mannose in FGlc-treated cells. This implies a role for vitamin A [68-26-8] in the dolichol cycle of protein glycosylation. This study involved multiple reactions and reactants, such as Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester (cas: 67341-43-9COA of Formula: C15H23FN2O16P2 ).
Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester (cas: 67341-43-9) belongs to tetrahydrofuran derivatives. Tetrahydrofuran and dihydrofuran form the basic structural unit of many naturally occurring scaffolds like gambieric acid A and ciguatoxin, goniocin, and some biologically active molecules. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.COA of Formula: C15H23FN2O16P2
67341-43-9;Uridine 5′-(trihydrogen diphosphate) P’-(2-deoxy-2-fluoro-α-D-glucopyranosyl) ester;The future of 67341-43-9;New trend of C15H23FN2O16P2 ;function of 67341-43-9