3′-Deoxyinosine as an antileishmanial agent: the metabolism and cytotoxic effects of 3′-deoxyinosine in Leishmania tropica promastigotes was written by Wataya, Yusuke; Hiraoka, Osamu. And the article was included in Biochemical and Biophysical Research Communications on September 17,1984.Category: tetrahydrofurans The following contents are mentioned in the article:
3′-Deoxyinosine is a potent growth inhibitor of the promastigote form of L. tropica. In culture, the EC50 value (50% growth inhibition) is 4.43 × 10-7M for the promastigote. On the other hand, it is less toxic ( EC50=1.25 × 10-4M) towards mouse mammary tumor FM3A cells. 3′-Deoxyinosine is metabolized by Leishmania promastigotes to give 3′-deoxyinosine-5′-monophosphate and 3′-deoxyadenosine(cordycepin)-5′-mono-, di-, and triphosphates. This metabolic conversion provides a mechanism for the parasite-selective toxicity of 3′-deoxyinosine: Leishmania can aminate the 6-position of 3′-deoxyinosine residue, thereby converting a less toxic nucleoside into the cordycepin nucleotides that are known to be highly toxic to cells. This study involved multiple reactions and reactants, such as 9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0Category: tetrahydrofurans).
9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol (cas: 13146-72-0) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. THF can also be synthesized by catalytic hydrogenation of furan. This allows certain sugars to be converted to THF via acid-catalyzed digestion to furfural and decarbonylation to furan, although this method is not widely practiced. THF is thus derivable from renewable resources.Category: tetrahydrofurans
13146-72-0;9-((2R,3R,5S)-3-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol;The future of 13146-72-0;New trend of C10H12N4O4 ;function of 13146-72-0