With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.124391-75-9,(S)-(Tetrahydrofuran-3-yl)methanol,as a common compound, the synthetic route is as follows.
To an ice-water cooled solution of (tetrahydrofuran-3-yl)methanol (2.0 g) in DCM (50 mL) wasadded TEA (5.5 mL) and then MsCI (2.3 mL) dropwise. The resulting mixture was warmed upslowly and stirred at RT for 2 hours. The mixture was quenched with aq. NaHCO3 solution, extracted with EA (3×100 mL). The combined organic layers were washed, dried andconcentrated to afford (tetrahydrofuran-3-yl)methyl methanesu Ifonate (3.2 g).
124391-75-9, The synthetic route of 124391-75-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CHEN, Weichun; IGBOKO, Ebere F; LIN, Xichen; LU, Hongfu; REN, Feng; WREN, Paul Bryan; XU, Zhongmiao; YANG, Ting; ZHU, Lingdong; WO2015/181186; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem