Analyzing the synthesis route of 124391-75-9

As the paragraph descriping shows that 124391-75-9 is playing an increasingly important role.

124391-75-9, (S)-(Tetrahydrofuran-3-yl)methanol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A stirred solution of 4-(2-hydroxyethyl)-morpholine (2.5mL, 20.7mmol) and Et3N (8.6mL, 62.0mmol) in anhydrous DCM (48mL) under N2 was cooled to 0¡ãC and then methanesulfonyl chloride (2.4mL, 31.0mmol) was added dropwise. The mixture was stirred at rt for 2h, filtered, the solid washed with minimal DCM and this filtrate combined with the original filtrate was evaporated under reduced pressure to give a yellow oil (10.24g) as a mixture of the desired product 2-(morpholin-4-yl)ethyl methanesulfonate and a salt (Et3NH+Cl+). This material was used without further purification. A stirred solution of 5-benzyloxyindole (600mg, 2.7mmol) in anhydrous DMF (11mL) under N2 was cooled to 0¡ãC, and then NaH (60percent by mass dispersion in mineral oil; 358mg, 9.0mmol) was added. The mixture was stirred at 0¡ãC for 10min and then at rt for 30min. The reaction mixture was cooled to 0¡ãC and a solution of 2-(morpholin-4-yl)ethyl methanesulfonate (1.13g, 5.4mmol) in anhydrous DMF (5mL) was added. The mixture was stirred at 45¡ãC for 2h, cooled to rt, diluted with EA (20mL) and quenched with sat. aq. NH4Cl (20mL) and H2O (10mL). The layers were separated and the aqueous layer extracted with EA (3¡Á20mL). The combined organics were washed with H2O (4¡Á70mL), dried over MgSO4, filtered and evaporated under reduced pressure. The crude product was purified using flash silica column chromatography (2:1PE:EA) to yield the desired 7a (690mg, 2.1mmol, 76percent) as a light brown wax (Rf 0.13, 2:1PE:EA)., 124391-75-9

As the paragraph descriping shows that 124391-75-9 is playing an increasingly important role.

Reference£º
Article; Cooper, Anna G.; MacDonald, Christa; Glass, Michelle; Hook, Sarah; Tyndall, Joel D.A.; Vernall, Andrea J.; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 770 – 789;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem