Product Details of 696-59-3In 2019 ,《Design, synthesis and antifungal activities of novel pyrrole- and pyrazole-substituted coumarin derivatives》 appeared in Molecular Diversity. The author of the article were Zhang, Shu-Guang; Liang, Chao-Gen; Sun, Yue-Qing; Teng, Peng; Wang, Jia-Qun; Zhang, Wei-Hua. The article conveys some information:
A series of novel pyrrole- and pyrazole-substituted coumarins, compounds I [R1 = H, Me, F, etc.; R2 = Me, CH2Cl, CF3, R3 = H, Me, etc.] and II [R4 = H, Me, Et, etc.; R5 = H, Me, etc.] and evaluated their antifungal activity against six phytopathogenic fungi in-vitro. The primary assay results demonstrated that some designed compounds displayed potent activities. Among them, compounds I [R1 = H, R2 = CH2Cl, R3 = Me] and II [R4 = H, Me, Et, R5 = Me; R4 = H’ R5 = CF3 R4R5 = (CH2)4]exhibited more effective control than Osthole against Cucumber anthrax and Alternaria leaf spot. Furthermore, compound I [R1 = H, R2 = CH2Cl, R3 = Me] displayed stronger antifungal activity against Rhizoctorzia solani (EC50 = 15.4 μg/mL) than pos. control Osthole (EC50 = 67.2 μg/mL). The results came from multiple reactions, including the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Product Details of 696-59-3)
2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Product Details of 696-59-3
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem