184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Production Example 230 (0550) Tetrahydrofuran-3-ylmethylamine hydrochloride (0.24 g, 1.75 mmol) and triethylamine (0.18 g, 1.75 mmol) were added to chloroform (amylene addition product) (8 mL). 5-(5,6,7,8-Tetrahydronaphthalen-2-yl)oxymethylisoxazole-3-c arboxylic acid (0.40 g, 1.46 mmol), 1-hydroxybenzotriazole (0.02 g, 0.18 mmol) and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (0.34 g, 1.75 mmol) were added to the mixture at room temperature, and the mixture was stirred for 5 hours. Then, dilute hydrochloric acid was added thereto, and the mixture was extracted twice with chloroform. The organic layer was washed with a saturated aqueous sodium bicarbonate solution, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain 0.40 g of N-(tetrahydrofuran-3-ylmethyl)-5-(5,6,7,8-tetrahydronaphtha len-2-yl)oxymethylisoxazole-3-carboxamide (hereinafter, referred to as Compound of Present Invention (239)) represented by the following formula. 1H-NMR(CDCl3, TMS, delta(ppm)):1.61-1.71(1H, m), 1.76-1.79 (4H, br m), 2.04-2.13(1H, m), 2.52-2.62(1H, m), 2.70-2.73(4H, br m), 3.44-3.48(2H, m), 3.57-3.60(1H, m), 3.73-3.79(1H, m), 3.83-3.94(2H, m), 5.15 (2H, s), 6.65(1H, br s), 6.69(1H, dd), 6.77(1H, s), 6.96(1H, br s), 6.99(1H, d), 184950-35-4
184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Tetrahydrofuran – Wikipedia
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