Saksena, Anil K.; Girijavallabhan, Viyyoor M.; Wang, Haiyan; Liu, Yi-Tsung; Pike, Russell E.; Ganguly, Ashit K. published their research in Tetrahedron Letters on August 5 ,1996. The article was titled 《Concise asymmetric routes to 2,2,4-trisubstituted tetrahydrofurans via chiral titanium imide enolates: key intermediates towards synthesis of highly active azole antifungals Sch 51048 and Sch 56592》.Application of 160709-02-4 The article contains the following contents:
Two complimentary approaches to the key (-)-(2R)-cis-tosylate I and its (+)-(2S)-enantiomer via generation of chiral imide enolates having a 2,2-disubstituted olefin functionality in the β-position, are described. In a “”protecting group free”” sequence, reaction of the titanium enolate generated from (4R)-benzyl-2-oxazolidinone derived imide II with s-trioxane provided a convenient oxazolidinone intermediate III which could be directly subjected to 2,4-diastereoselective iodocycln. In the experimental materials used by the author, we found ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4Application of 160709-02-4)
((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methanol(cas: 160709-02-4) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Application of 160709-02-4
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem