《Regioselective condensation of hydroxyaromatic compounds with 2,5-dimethoxytetrahydrofuran: facile one-pot synthesis of new substituted diaryl-fused 2,8-dioxabicyclo[3.3.2]nonanes comprising central ketal moieties》 was published in New Journal of Chemistry in 2020. These research results belong to Rahmatpour, Ali. SDS of cas: 696-59-3 The article mentions the following:
A tandem one-pot double Friedel-Crafts alkylation/intramol. double cyclization process to conveniently assemble diaryl-fused 2,8-dioxabicyclo[3.3.2]nonanes with aryl substituents at the C-2 (β) position was developed. A series of new sym. 2,8-dioxabicyclo[3.3.2]nonanes fused with two Ph and two naphthyl groups was synthesized through a straightforward, one-pot protocol based on a two-component regioselective condensation reaction starting from 2,5-dimethoxytetrahydrofuran, p-substituted phenols and 2-naphthol, resp., using p-toluenesulfonic acid (PTSA) as a catalyst in methylene chloride in moderate to good yields and various substitutions on one reaction partner were tolerated. Four chem. bonds (two C-C bonds and two C-O bonds) and two seven-membered cycles were formed in a one-pot operation. In the case of condensation of 2,7-dihydroxynaphthalene with 2,5-dimethoxytetrahydrofuran, 8,16-ethano-16H-dinaphtho[2,1-d:1′,2′-g][1,3]dioxocin-2,14-diol was obtained in good yield.2,5-Dimethoxytetrahydrofuran(cas: 696-59-3SDS of cas: 696-59-3) was used in this study.
2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.SDS of cas: 696-59-3
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem