HPLC of Formula: 696-59-3In 2021 ,《N,N-Dimethylformamide as Carbon Synthons for the Synthesis of N-Heterocycles: Pyrrolo/Indolo[1,2-a]quinoxalines and Quinazolin-4-ones》 appeared in Journal of Organic Chemistry. The author of the article were Li, Shichen; Ren, Jianing; Ding, Chengcheng; Wang, Yishou; Ma, Chen. The article conveys some information:
N,N-dimethylformamide (DMF) as synthetic precursors contributing especially the Me, acyl, and amino groups has played a significant role in heterocycle syntheses and functionalization. In this protocol, a wide range of pyrrolo[1,2-a]quinoxalines I (R = H, Cl, Me; R1 = H, Cl, Me; R2 = H, Cl, F, Br, Me, OMe; R3 = H, Cl, F, Br, Me, CN), II /indolo[1,2-a]quinoxalines III (R4 = H, Cl, Me, CN, etc.; R5 = H, F, Cl, Me) and quinazolin-4-ones IV (R6 = H, 4-Cl, 4-NO2, 5-Fl, 5-Br; R7 = n-Bu, cyclohexyl, Ph, Bn, etc.) were obtained in moderate to good yields by using elemental iodine without any metal or peroxides. N-Me and N-acyl of DMF that participate and complete the reaction sep. through different mechanisms, which displayed potential still to be explored of DMF were considered. In addition to this study using 2,5-Dimethoxytetrahydrofuran, there are many other studies that have used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3HPLC of Formula: 696-59-3) was used in this study.
2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.HPLC of Formula: 696-59-3
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem