88675-24-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88675-24-5,Tetrahydrofuran-3-amine,as a common compound, the synthetic route is as follows.
TEA (507 mu, 3.64 mmol) was added dropwise to 2-((4-bromo-2- nitrophenyl)amino)acetic acid (500 mg, 1.818 mmol), HATU (864 mg, 2.272 mmol) 5 and tetrahydrofuran-3 -amine (198 mg, 2.272 mmol) in DCM (5 mL) and the resulting dark red mixture was stirred at room temperature for 2 hours. The mixture was treated with sodium hydrogenocarbonate (20 mL) and the precipitate filtered off and washed with water (3 x 20 mL). Flash chromatography (0-100percent EtOAc+lpercentMeOH in iso- hexanes, 40 g silica) gave 2-((4-bromo-2-nitrophenyl)amino)-N-(tetrahydrofuran-3- [0 yl)acetamide (382 mg, 59percent) as a orange solid; m/z 344/346 (M+H)+ (ES+).
The synthetic route of 88675-24-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CELLCENTRIC LTD; PEGG, Neil Anthony; TADDEI, David Michel Adrien; ONIONS, Stuart Thomas; TSE, Eric Sing Yuen; BROWN, Richard James; MYCOCK, David Kenneth; COUSIN, David; PATEL, Anil; (135 pag.)WO2016/170324; (2016); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem