Kiani, Salma; Staples, Richard J.; Ted Treves, S.; Packard, Alan B. published the artcile< Synthesis and characterization of a tetramethyl furanone functionalized diiminedioxime, a potential ligand for 64Cu radiopharmaceuticals, and its copper(II) and nickel(II) complexes>, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one, the main research area is copper nickel furanone functionalized imineoxime preparation structure; crystal structure copper nickel furanone functionalized imineoxime; furanone functionalized imineoxime preparation potential radiopharmaceutical imaging ligand.
As part of the authors’ on-going effort to develop 64Cu-based radiopharmaceuticals for PET (positron emission tomog.) imaging of multidrug resistance in cancer, the authors prepared a tetramethylfuranone-functionalized diiminedioxime ligand, TMFPreH (TMFPreH = 4-[3-(4-hydroxyimino-2,2,5,5-dimethyl-dihydro-furan-3-ylideneamino)-propylimino]-2,2,5,5-tetramethyl-dihydrofuran-3(2H)-one oxime) and its Cu(II) and Ni(II) complexes. When the Cu(II) complex was prepared from Cu(ClO4)2 in EtOH, it was isolated as a Cu(II)-bridged dimer, but when it was prepared from Cu(OAc)2 and heated in acetone, an unusual example of an acetone adduct of the ligand is formed by reduction of one of the imine double bonds by the solvent. The Ni(II) complex is square planar with the perchlorate counterion not bonded.
Polyhedron published new progress about Crystal structure. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one.
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem