Chen, Jianzhong; Zhang, Zhenfeng; Li, Bowen; Li, Feilong; Wang, Yulin; Zhao, Min; Gridnev, Ilya D.; Imamoto, Tsuneo; Zhang, Wanbin published the artcile< Pd(OAc)2-catalyzed asymmetric hydrogenation of sterically hindered N-tosylimines>, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one, the main research area is tosylamine preparation enantioselective; tosylimine preparation hydrogenation palladium catalyst.
An efficient palladium acetate (an inexpensive Pd salt with low toxicity) catalyzed asym. hydrogenation of sterically hindered N-tosylimines RC(R1)=NS(O)2R2 (R = t-Bu, 1-methoxycyclohexyl, adamantan-1-yl, etc.; R1 = Ph, 2H-1,3-benzodioxol-5-yl, Me, etc.; R2 = Ph, Me, 4-FC6H4, etc.), (E)-N-(2,2-Dimethylcyclopentylidene)-4-methylbenzenesulfonamide and (E)-4-Methyl-N-(2,2,5,5-tetramethyldihydrofuran-3(2H)-ylidene)benzenesulfonamide is realized with high catalytic activities (S/C up to 5000) and excellent enantioselectivities (ee up to 99.9%). Quantum chem. calculations suggest that uniformly high enantioselectivities are observed due to the structurally different S- and R-reaction pathways.
Nature Communications published new progress about Amines, chiral Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (tosyl). 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Recommanded Product: 2,2,5,5-Tetramethyldihydrofuran-3(2H)-one.
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem