(2R,3S,4S,5S)-5-(Acetoxymethyl)tetrahydrofuran-2,3,4-triyl triacetate(cas:144490-03-9 HPLC of Formula: 144490-03-9) is an isomer of 1,2,3,5-Tetra-O-acetyl β-D-Ribofuranose (T283100) which is used in the synthesis of 3-(β-D-ribofuranosyl)-2,3-dihydro-6H-1,3-oxazine-2,6-dione, a new pyrimidine nucleoside analog related to uridine.
Hocek, Michal;Silhar, Peter;Shih, I-hung;Mabery, Eric;Mackman, Richard published 《Cytostatic and antiviral 6-arylpurine ribonucleosides. Part 7: Synthesis and evaluation of 6-substituted purine L-ribonucleosides》 in 2006. The article was appeared in 《Bioorganic & Medicinal Chemistry Letters》. They have made some progress in their research.HPLC of Formula: 144490-03-9 The article mentions the following:
A series of purine L-ribonucleosides bearing diverse C-substituents (alkyl, aryl, hetaryl or hydroxymethyl) in the position 6 were prepared by Pd-catalyzed cross-coupling reactions of 6-chloro-9-(2,3,5-tri-O-acetyl-β-L-ribofuranosyl)purine with the corresponding organometallics followed by deprotection. Unlike their L-ribonucleoside enantiomers that possess strong cytostatic and anti-HCV activity, the L-ribonucleosides were inactive except for 6-benzylpurine nucleoside showing moderate anti-HCV effect in replicon assay. A triphosphate of the 6-benzylpurine nucleoside did not inhibit HCV RNA polymerase.(2R,3S,4S,5S)-5-(Acetoxymethyl)tetrahydrofuran-2,3,4-triyl triacetate (cas: 144490-03-9) were involved in the experimental procedure.
(2R,3S,4S,5S)-5-(Acetoxymethyl)tetrahydrofuran-2,3,4-triyl triacetate(cas:144490-03-9 HPLC of Formula: 144490-03-9) is an isomer of 1,2,3,5-Tetra-O-acetyl β-D-Ribofuranose (T283100) which is used in the synthesis of 3-(β-D-ribofuranosyl)-2,3-dihydro-6H-1,3-oxazine-2,6-dione, a new pyrimidine nucleoside analog related to uridine.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem