Recommanded Product: (3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methanoisobenzofuran-1,3-dione《Study of Chemical Shift Variations in Tricyclic Urazoles with a Norbornane Skeleton》 was published in 2006. The authors were Bentz, Timothy;Ryzhkov, Lev, and the article was included in《Spectroscopy Letters》. The author mentioned the following in the article:
Mols. related to norbornane commonly serve as useful models for stereochem. and conformational anal., as well as for elucidation of steric and electronic substituent effects. Chem. shifts of their bridge protons are well tabulated and follow clear, easily predictable patterns. For example, the exo protons on a two-carbon bridge of these mols. are typically deshielded relative to the endo protons. Previously, some exceptions to this rule were noted and satisfactorily explained. In tricyclic urazoles, common precursors to cyclic diazenes, the order of chem. shifts of exo and endo bridge protons is reversed. The authors use aromatic solvent induced shifts (ASIS) and homodecoupling experiments to assign 1H-NMR signals in these urazoles and bridge proton signals in model mols., and the authors discuss anal. of factors that influence chem. shifts in this polycyclic system. The experimental procedure involved many compounds, such as (3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methanoisobenzofuran-1,3-dione (cas: 14166-28-0) .
In the laboratory, (3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methanoisobenzofuran-1,3-dione(14166-28-0) is a popular solvent when its water miscibility is not an issue. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes.Recommanded Product: (3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methanoisobenzofuran-1,3-dione It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem