Application In Synthesis of (S)-Butan-2-ol. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-Butan-2-ol, is researched, Molecular C4H10O, CAS is 4221-99-2, about Decarboxylative Ritter-Type Amination by Cooperative Iodine (I/III)-Boron Lewis Acid Catalysis.
Recent years have witnessed important progress in synthetic strategies exploiting the reactivity of carbocations via photochem. or electrochem. methods. Yet, most of the developed methods are limited in their scope to certain stabilized positions in mols. Herein, Author report a metal-free system based on the iodine (I/III) catalytic manifold, which gives access to carbenium ion intermediates also on electronically disfavored benzylic positions. The unusually high reactivity of the system stems from a complexation of iodine (III) intermediates with BF3. The synthetic utility of decarboxylative Ritter-type amination protocol has been demonstrated by the functionalization of benzylic as well as aliphatic carboxylic acids, including late-stage modification of different pharmaceutical mols. Notably, the amination of ketoprofen was performed on a gram scale. Detailed mechanistic investigations by kinetic anal. and control experiments suggest two mechanistic pathways.
This compound((S)-Butan-2-ol)Application In Synthesis of (S)-Butan-2-ol was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem