Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3066-84-0, is researched, SMILESS is NC(N1)=NC(NC(Br)=N2)=C2C1=O, Molecular C5H4BrN5OJournal, Article, European Journal of Pharmaceutics and Biopharmaceutics called Scaffold hopping identifies 6,8-disubstituted purines as novel anaplastic lymphoma kinase inhibitors, Author is Schluetke, Laura; Immer, Markus; Preu, Lutz; Totzke, Frank; Schaechtele, Christoph; Kubbutat, Michael H. G.; Kunick, Conrad, the main research direction is purine derivative anaplastic lymphoma kinase inhibitor; Anaplastic lymphoma kinase, ALK; EML4-ALK fusion; Gatekeeper mutation; Protein kinase inhibitor; Purine; Scaffold hopping; Solubility; Thieno[3,2-d]pyrimidine; c-Met.Safety of 8-Bromoguanine.
Rearrangements of anaplastic lymphoma kinase (ALK) are associated with several cancer diseases. Due to resistance development against existing ALK-inhibitors, new, structurally unrelated inhibitors are required. By a scaffold hopping strategy, 6,8-disubstituted purines were designed as analogs of similar ALK-inhibiting thieno[3,2-d]pyrimidines. While the new title compounds indeed inhibited ALK and several ALK mutants in submicromolar concentrations, they retained poor water solubility
This compound(8-Bromoguanine)Safety of 8-Bromoguanine was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem