In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Organocatalytic Diastereoselective Synthesis of Diazoaryl-benzo[b]azepine Derivatives, published in 2020-06-05, which mentions a compound: 20028-53-9, mainly applied to arylazo benzazepinecarboxylate diastereoselective preparation; binaphthylphosphoric acid catalyst tandem cyclocondensation aminobenzaldehyde hydrazone unsaturated ketoester, Quality Control of 2-Amino-5-chlorobenzaldehyde.
In the presence of racemic 1,1′-binaphthalene-2,2′-diyl phosphoric acid, 2-aminobenzaldehyde aryl hydrazones 5-R1-2H2NC6H3CH:NNHR2 (R1 = H, Cl; R2 = Ph, 4-MeOC6H4, 2,5-Me2C6H3, 4-FC6H4, 4-BrC6H4) underwent tandem cyclocondensation reactions with (E)-γ-aryl-β,γ-unsaturated-α-keto esters (E)-RCH:CHCOCO2R3 (R = Ph, 4-MeC6H4, 4-BrC6H4, 4-ClC6H4, 3-ClC6H4; R3 = Me, Et, i-Pr, t-Bu) to yield arylazodihydrobenzazepinecarboxylates I (R = Ph, 4-MeC6H4, 4-BrC6H4, 4-ClC6H4, 3-ClC6H4; R1 = H, Cl; R2 = Ph, 4-MeOC6H4, 2,5-Me2C6H3, 4-FC6H4, 4-BrC6H4; R3 = Me, Et, i-Pr, t-Bu) in 89-99% yields and in >19:1 dr.
This compound(2-Amino-5-chlorobenzaldehyde)Quality Control of 2-Amino-5-chlorobenzaldehyde was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem