COA of Formula: C13H20N4O2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, is researched, Molecular C13H20N4O2, CAS is 1028-33-7, about Cerebral blood flow effects of piracetam, pentifylline, and nicotinic acid in the baboon model compared with the known effect of acetazolamide. Author is Jordaan, Beatrice; Oliver, Douglas W.; Dormehl, Irene C.; Hugo, Niek.
In normal aging humans there is a progressive decrease of oxygen and glucose consumption with a reduction of cerebral blood flow (CBF), which could be responsible for age related changes in cognitive functions. A baboon model under anesthesia using single photon emission computed tomog. (SPECT) of the brain and the radiopharmaceutical hexamethylpropylene amine oxime (99mTc-HMPAO) was developed and found to be sensitive to the effects of drugs that are known to increase CBF. The effect of two haemorrheol. active drugs, viz a combination of pentifylline (I) and nicotinic acid (II) vs. piracetam (III) were compared with the known effect of acetazolamide (IV) on CBF in the baboon model. IV and the combination of I and II increased the CBF when compared with the control baseline. The CBF was not significantly increased upon treatment with III, I alone, and II alone, when compared with the control values for total brain ratios. However, an increased regional effect was observed for III. These results indicate that the above haemorrheol. active drugs exhibit specific but different effects on cerebral blood flow with possible clin. implications.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem