COA of Formula: C7H6ClNO. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Amino-5-chlorobenzaldehyde, is researched, Molecular C7H6ClNO, CAS is 20028-53-9, about Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties. Author is Pinto, Donald J. P.; Smallheer, Joanne M.; Corte, James R.; Austin, Erin J. D.; Wang, Cailan; Fang, Tianan; Smith, Leon M.; Rossi, Karen A.; Rendina, Alan R.; Bozarth, Jeffrey M.; Zhang, Ge; Wei, Anzhi; Ramamurthy, Vidhyashankar; Sheriff, Steven; Myers, Joseph E.; Morin, Paul E.; Luettgen, Joseph M.; Seiffert, Dietmar A.; Quan, Mimi L.; Wexler, Ruth R..
Compound 2 was previously identified as a potent inhibitor of factor XIa lacking oral bioavailability. A structure-based approach was used to design analogs of 2 with novel P1 moieties with good selectivity profiles and oral bioavailability. Further optimization of the P1 group led to the identification of a 4-chlorophenyltetrazole P1 analog, which when combined with further modifications to the linker and P2′ group provided compound 32 with FXIa Ki = 6.7 nM and modest oral exposure in dogs.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem