Synthetic Route of C7H6ClNO. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Amino-5-chlorobenzaldehyde, is researched, Molecular C7H6ClNO, CAS is 20028-53-9, about Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors. Author is Lin, Jian; Lu, Wei; Caravella, Justin A.; Campbell, Ann Marie; Diebold, R. Bruce; Ericsson, Anna; Fritzen, Edward; Gustafson, Gary R.; Lancia, David R.; Shelekhin, Tatiana; Wang, Zhongguo; Castro, Jennifer; Clarke, Andrea; Gotur, Deepali; Josephine, Helen R.; Katz, Marie; Diep, Hien; Kershaw, Mark; Yao, Lili; Kauffman, Goss; Hubbs, Stephen E.; Luke, George P.; Toms, Angela V.; Wang, Liann; Bair, Kenneth W.; Barr, Kenneth J.; Dinsmore, Christopher; Walker, Duncan; Ashwell, Susan.
Mutations at the arginine residue (R132) in isocitrate dehydrogenase 1 (IDH1) are frequently identified in various human cancers. Inhibition of mutant IDH1 (mIDH1) with small mols. has been clin. validated as a promising therapeutic treatment for acute myeloid leukemia and multiple solid tumors. Herein, we report the discovery and optimization of a series of quinolinones to provide potent and orally bioavailable mIDH1 inhibitors with selectivity over wild-type IDH1. The X-ray structure of an early lead 24 in complex with mIDH1-R132H shows that the inhibitor unexpectedly binds to an allosteric site. Efforts to improve the in vitro and in vivo absorption, distribution, metabolism, and excretion (ADME) properties of 24 yielded a preclin. candidate 63. The detailed preclin. ADME and pharmacol. studies of 63 support further development of quinolinone-based mIDH1 inhibitors as therapeutic agents in human trials.
After consulting a lot of data, we found that this compound(20028-53-9)Synthetic Route of C7H6ClNO can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem